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eISSN: 1643-3750

Beta-carotene and vitamin A serum concentration in children with progressive familial intrahepatic cholestasis with complete relief cholestasis after ursodeoxycholic acid or surgical treatment

I. Jankowska, P. Socha, J. Pawłowska, J. Łukaszewicz, P. Kaliciński, H. Ismail, J. Socha

Med Sci Monit 2003; 9(2): 20-

ID: 15302

Published: 2003-05-20


Background: Some previous studies have shown that beta-carotene is poorly absorbed in some malabsorptive states (e.g.cystic fibrosis). There are only a few reports of serum beta-carotene con- centration in children with progressive familial intrahepatic cholestasis (PFIC). The aim of study was to estimate beta-carotene and vitamin A concentration in children with PFIC after pharmacological (ursodeoxycholic acid –UDCA)or surgical (partial external biliary diversion – PEBD)),with complete relief of cholestasis. Material/Methods: We studied 24 children with PFIC (15 boys and 9 girl)aged 2 to 18 years with complete relief of pruritus and jaundice and normalisation of bile acids concentration (

Keywords: progressive familial intrahepatic cholestasis



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