I. Ciećko-Michalska, J. Bogdał, M. Szczepanek, D. Skulina, W. Szczepański, M. Michalski
Med Sci Monit 2003; 9(2): 7-
Available online: 2003-05-20
Background:Assessment of serum level of cytokines:IL-2, IL-4,IL-6,IL-8,IL-10,TNF-alfa and CRP in patients with alcoholic hepatitis and alcoholic liver cirrhosis. Attempt to find their correlation with clinical stage and life prognosis in all patients.Material/Methods:We examined 24 patients with alcoholic liver disease, hospitalised in Department of Gastroenterology: 13 male and 11 female at the age 26 –72 years. According to clinical symptoms in 15 of them alcoholic hepatitis (in 9 confirmed by the liver biopsy) and in 9 -liver cirrhosis (2 confirmed by the liver biopsy) were diagnosed. The interview, physical examination, abdominal ultrasound, biochemical tests and viral tests were performed in all patients. We excluded patients with viral liver lesion,treated with steroids and cytostatics. Serum level of cytokines and CRP were established three times during the first week of hospitalisation.
Results/Conclusions:In all patients IL-2 and IL-4 levels were in a range characteristic for healthy people. There was statistically important correlation between the severe clinical stage and high level of serum IL-6 (p