Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 May 2003

PARP-inhibitors for ischemia-reperfusion injury of the liver

H. Mota-Filipe

Med Sci Monit 2003; 9(1): 46- :: ID: 15109

Abstract

Ischemia-reperfusion (I/R) is responsible for the development of liver dysfunction and failure in several clinical conditions including liver transplantation and hemorrhagic shock. At the present, there is no pharmacological intervention proven to either attenuate liver cell injury or to augment tissue regeneration of the liver after acute or chronic injury of this organ. The occurrence of oxidant-mediated damage resulting from I/R has been demonstrated in several different animal models [1,2], where the generation of reactive oxygen species contributes to DNA damage [3]. One possible way of oxidant-induced injury involves the excessive activation of the nuclear enzyme poly-(ADP-ribose) polymerase (PARP).Using a rat model of liver I/R, we have the effects of the water-soluble PARP-inhibitor 5-aminoisoquinoline (5-AIQ) on liver injury (transaminases, histopathology), the upregulation of the adhesion molecule intracellular adhesion molecule 1 (ICAM-1) and the increase in PARP activity (measured as immunoreactivity of PAR), and the degree of lipid peroxidation caused by ischaemia and reperfusion (I/R) of the liver. When compared to control, 5-AIQ reduced the I/R-induced rise in the serum levels of transaminases, lactate dehydrogenase, and g-glutamyl transferase as well as the degree of lipid peroxidation. Liver sections obtained from 5-AIQ treated rats showed reduced PARP activation and less staining for ICAM-1. The role that PARP plays in the process of recovery that follows I/R injury to the liver will be discussed. References: 1.Caldwell-Kendel JC, Currin RT, Tanaka Y et al: Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology, 1989; 10: 92-9 2.Schoenberg MH, Muhl E, Sellin D et al: Posthypotensive generation of superoxide free-radicals – possible role in the pathogenesis of the intestinal mucosal damage. Acta Chir Scand, 1984; 150: 301-9 3.Martin D, Lewington A, Hammerman M, Padanilam B: Inhibition of poly (ADP-ribose) polymerase attenuates ischemic renal injury in rats. Am J Physiol Regulatiry Integrative Comp Physiol, 2000; 279: 1834-40

Keywords: Liver, ischemia-reperfusion, PARP, 5-aminoisoquinoline

Comments

Editorial

01 May 2022 : Editorial  

Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937048

Med Sci Monit 2022; 28:e937048

SARS-CoV-2/COVID-19

24 May 2022 : Clinical Research  

Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...

Med Sci Monit In Press; DOI: 10.12659/MSM.936962  

04 May 2022 : Clinical Research  

Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936069  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

27 May 2022 : Clinical Research  

Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular...

Med Sci Monit In Press; DOI: 10.12659/MSM.937005  

25 May 2022 : Review article  

Narrative Review of the Mechanism of Hip Prosthesis Dislocation and Methods to Reduce the Risk of Dislocation

Med Sci Monit In Press; DOI: 10.12659/MSM.935665  

24 May 2022 : Clinical Research  

Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936580  

24 May 2022 : Clinical Research  

Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...

Med Sci Monit In Press; DOI: 10.12659/MSM.936962  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750