08 September 2003
Atrial fibrillation and electrical remodeling: the potential role of inflammation and oxidative stressPanagiotis Korantzopoulos, Theofilos Kolettis, Kostas Siogas, John Goudevenos
Med Sci Monit 2003; 9(9): RA225-229 :: ID: 13210
Atrial fibrillation (AF) represents the most common arrhythmia encountered in clinical practice. The pathophysiology of AF is complex, but in most cases it may be caused by multiple random re-entering wavelets. As generally known, the development of AF leads to electrophysiological and cellular changes in the atria that tend to sustain AF, a process known as electrical remodeling. In addition, it has been proposed that electrical remodeling contributes to the high incidence of early recurrence of AF after cardioversion. The principal characteristics of this process are the shortening of the refractory period with increased dispersion, the loss of rate adaptation, and the reduction of atrial conductivity. On the molecular level, calcium accumulation in myocytes seems to trigger electrophysiological changes leading to reduction in the intensity of L-type calcium current. Currently, the role of inflammation and oxidative stress on electrical remodeling is under investigation. C-reactive protein (CRP), a major inflammatory marker, has been found to be increased in both persistent and paroxysmal AF. Additionally, CRP may have prognostic significance regarding successful cardioversion of AF, and may predict recurrences of arrhythmia. On the other hand, it has been demonstrated that increased oxidative damage occurs in the atria of AF patients and may contribute to electrical remodeling. Interestingly, a prodromal antioxidant intervention study showed beneficial effects from vitamin C on incidence of postoperative AF. The role of inflammation and oxidative stress in AF deserves further study, since amelioration of atrial electrical remodeling by conventional antiarrhythmics has been proved ineffective.
Keywords: Inflammation - physiopathology
27 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)
Med Sci Monit 2021; 27:e934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
09 July 2021 : Database AnalysisA Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...
Med Sci Monit In Press; DOI: 10.12659/MSM.931467
27 Sep 2021 : Clinical ResearchEffect of Combined Thoracic Paravertebral Block and General Anesthesia vs General Anesthesia Alone on Posto...
Med Sci Monit In Press; DOI: 10.12659/MSM.933623
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700