27 August 2003
Lymphocyte subsets differences in smokers and nonsmokers with primary lung cancer: a flow cytometry analysis of bronchoalveolar lavage fluid cellsGrażyna Hoser, Joanna Domagała-Kulawik, Paweł Droszcz, Wacław Droszcz, Jerzy Kawiak
Med Sci Monit 2003; 9(8): BR310-315 :: ID: 13092
Background:Tobacco smokers are at a higher risk of lung cancer than nonsmokers. This may be a result of changes in immunological status. The aim of this study was to evaluate lymphocyte phenotypes in the peripheral airways of patients with lung cancer and healthy subjects in relation to smoking history.Material/Methods:BALF cells from patients with primary lung cancer and from healthy smokers and nonsmokers were analyzed by a flow cytometry method using monoclonal antibodies directed to subpopulations of lymphocytes.Results:The total cell count was elevated in the BALF from smokers. We found a low proportion of T helper (Th) and high proportion of T suppressor/cytotoxic (T s/c) cells in the BALF from smokers with lung cancer. The ratios of Th to T cells and Th to Ts/c cells were significantly lower, and the ratio of Ts/c to T cells was significantly higher in the BALF from the lung cancer patients than from healthy controls. The ratios of Th to Ts/c and Th to T cells were significantly lower in the BALF of the smoking controls when compared to nonsmoking controls. The proportion of T activated cells was lower in the group of smokers with lung cancer when compared with healthy smokers.Conclusions:We found significant differences in lymphocyte subpopulations in BALF between lung cancer patients and healthy persons and between smokers and nonsmokers. Smoking history should be taken into consideration in the analysis of BALF cells.
Keywords: Adult, Aged, 80 and over, Bronchoalveolar Lavage Fluid - cytology, Lung Neoplasms - immunology, Lung Neoplasms - pathology, Lymphocyte Subsets, Smoking
This Week Editorial
20 September 2021 : EditorialEditorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19
Med Sci Monit 2021; 27:e934766
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
09 July 2021 : Database AnalysisA Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...
Med Sci Monit In Press; DOI: 10.12659/MSM.931467
20 Sep 2021 : Clinical ResearchComparison of the Use of Magnetic Resonance Imaging of Partial Anterior Cruciate Ligament Tears Using Maxim...
Med Sci Monit In Press; DOI: 10.12659/MSM.932228
20 Sep 2021 : Clinical ResearchAutomated Boluses and Delayed-Start Timers Prolong Perineural Local Anesthetic Infusions and Analgesia Foll...
Med Sci Monit In Press; DOI: 10.12659/MSM.933190
16 Sep 2021 : Clinical ResearchA Retrospective Evaluation of Operative and Postoperative Outcomes in Patients with Spinal Metastases from ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932995
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700