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Prevalence of Anticardiolipin Antibody IgG in Recurrent First Trimester Abortions and the Role of Aspirin in Its Prevention

Sunita Kalra, Anita Tuli, Rewa Choudhry, Shashi Raheja

Med Sci Monit 2003; 9(6): CR213-216

ID: 12712

Available online: 2003-06-25

Published: 2003-06-25

Background:Approximately 10% of all human pregnancies end in spontaneous abortions. In the majority of such cases the etiology remains unknown, but anticardiolipin antibodies are gaining recognition as potential causes of recurrent miscarriage.Material/Methods:The prevalence of anticardiolipin antibody IgG (IgGacl) in 60 pregnant patients with recurrent first trimester abortions and 60 pregnant controls of comparable age with no history of abortion were examined to find a possible relation between IgGacl and spontaneous abortion. The assay for IgGacl was done by Enzyme Linked Immunosorbent Assay (ELISA). Positive test results were considered ‘strongly elevated’ with IgGacl levels exceeding 36 GPL units. Aspirin (80 mg per day) was prescribed for patients with recurrent first trimester abortion and strongly elevated levels of IgGacl.Results:Strongly elevated levels of IgGacl were detected in a total of 18 patients (30%) with recurrent abortions, and none of the controls (p

Keywords: Abortion, Habitual - blood, Abortion, Habitual - immunology, Abortion, Habitual - prevention & control, Anti-Inflammatory Agents, Non-Steroidal - therapeutic use, Antibodies, Anticardiolipin - blood, Aspirin - therapeutic use, Immunoglobulin G - blood, Pregnancy, Pregnancy Trimester, First - immunology, Reproducibility of Results, Risk