Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

16 June 2004

GABA in ischemic stroke. Proton magnetic resonance study

Lidia Głodzik-Sobańska, Agnieszka Słowik, Justyna Kozub, Barbara Sobiecka, Andrzej Urbanik, Andrzej Szczudlik

Med Sci Monit 2004; 10(3): 88-93 :: ID: 11869

Abstract

Background:Experimental studies have suggested that ischemic stroke causes increment in extracellular level of gamma-aminobutyric acid in response to excessive glutamate concentration and function. The increased GABA concentration is followed by subsequent inhibition of GABA synthesis, thus leading to GABA-ergic dysfunction Enhancing GABA function seems to be a way of neuroprotec- tion after cerebral insult.
Animal models have shown there is overactivity of excitatory neurotransmitters and decreased tone of GABA-ergic system also in the remote neocortical regions. Data concerning changes in brain areas outside the stroke lesion in humans are sparse. These region could be possible targets for therapeutic intervention. Progress in imaging techniques enables separation of a great number of chemical compounds .Our aim was to assess GABA levels outside the ischemic lesion by means of proton magnetic resonance spectroscopy ([sup]1[/sup] H MRS).Material/Methods: The study compared 31 patients with first-ever ischemic stroke and 20 healthy subjects. Single voxel H[sup] 1[/sup] MRS was performed to measure GABA/Cr ratios in structurally normal prefrontal regions, distant from the stroke lesion. The amount of the remaining metabolites (NAA, Cho, mI, Glx) was also estimated. Patients underwent the examination in the acute phase of the disease and 3 months later.Results: Both early after stroke and more than 3 months later, the patients had lower GABA levels. However, during the second examination, this difference was evident only in the frontal cortex ipsilateral to the lesion.Conclusions: These findings suggest that GABA function is decreased outside the infarct. Further studies are needed for confirmation of the results and elucidation of the possible role of GABA alterations in stroke recovery and therapy.

Keywords: proton magnetic resonance spectroscopy, Stroke, GABA

0 Comments

This Week Editorial

13 September 2021 : Editorial

Editorial: The First Monoclonal Antibody Vaccine to Prevent Malaria Heralds a New Era of Malaria Vaccines to the Plasmodium falciparum Circumsporozoite Protein (PfCSP)

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934676

Med Sci Monit 2021; 27:e934676

Coronavirus/Covid 19

15 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of...

Med Sci Monit In Press; DOI: 10.12659/MSM.934766  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

16 Sep 2021 : Clinical Research

A Retrospective Evaluation of Operative and Postoperative Outcomes in Patients with Spinal Metastases from ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932995  

15 Sep 2021 : Clinical Research

Polish Medical Air Rescue Interventions Concerning Pregnant Women in Poland: A 10-year Retrospective Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.933029  

15 Sep 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of...

Med Sci Monit In Press; DOI: 10.12659/MSM.934766  

15 Sep 2021 : Clinical Research

A Prospective Single-Center Study of the Effects of Repetitive Transcranial Magnetic Stimulation at 2-Week ...

Med Sci Monit In Press; DOI: 10.12659/MSM.933017  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750