Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 October 2004

Influence of preischemic short-term triiodothyronine administration on hemodynamic function and metabolism of reperfused isolated rat heart

Piotr Kazmierczak, Anna Polak, Mirosław Mussur

Med Sci Monit 2004; 10(10): BR381-387 :: ID: 11785

Abstract

Background:The “euthyroid sick syndrome” may intensify dysfunction of the heart during acute myocardial ischemia. The present research was undertaken to outline the effects of preischemic short-term triiodothyronine (T[sub]3[/sub]) administration on hemodynamic function and metabolism of the myocardium during reperfusion.Material/Methods: Thirty-six isolated working rat hearts were assigned to three experimental groups and a control group. The hearts were removed from the animals and perfused in the modified Langendorff model. They were subjected to 30 minutes of initial perfusion, 40 minutes of ischemia, and 15 minutes of reperfusion. The experimental groups received 10 extra minutes of T[sub]3[/sub] administration followed by initial perfusion (concentration of T[sub]3[/sub] was: group 1–5.4 pmol/l, group 2–27 pmol/l, and group 3–54 pmol/l). Control hearts received perfusate without T[sub]3[/sub]. We evaluated the postischemic recovery of left ventricular function (aortic pressures, heart rate, cardiac output), coronary flow, and oxygen consumption.Results: Progressive percentage of recovery of aortic systolic pressure, aortic mean pressure, and cardiac output with increasing concentration of T[sub]3[/sub] was observed. Cardiac output reached the best recovery in the group with the highest concentration of T[sub]3[/sub] (80.9±7.5%) and was significantly better in comparison with the control group and the other experimental groups. No significant differences in coronary flow and oxygen consumption were noted.Conclusions: Triiodothyronine administered before ischemia improves postischemic left ventricular function with no changes in oxygen consumption and coronary flow.

Keywords: Triiodothyronine - administration & dosage, Coronary Circulation - drug effects, Coronary Vessels - drug effects, Heart - physiology, Hemodynamics - drug effects, Myocardial Ischemia - metabolism, Myocardium - metabolism, Oxygen - metabolism, Oxygen Consumption - drug effects, Rats, Wistar, Reperfusion, Time Factors, Triiodothyronine - pharmacology

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750