Resistin levels in patients with obstructive sleep apnoea syndrome--the link to subclinical inflammation?
Igor Alexander Harsch, Corinna Koebnick, Henri Wallaschofski, Simin Pour Schahin, Eckhart Georg Hahn, Joachim Hans Ficker, Tobias Lohmann, Peter Christopher Konturek
Med Sci Monit 2004; 10(9): CR510-515
Available online: 2004-09-01
BACKGROUND: The role of resistin, a "new" white adipose tissue hormone, still needs to be established. Its linkage to insulin sensitivity and body mass was controversial in previous studies. MATERIAL/METHODS: Twenty obese patients (BMI: 32.1+/-6.9 kg/m2 ) with obstructive sleep apnoea syndrome (OSAS) (Apnoea-Hypopnoea Index: 48.6+/-19.1, underwent measurements of resistin, interleukin-6 (IL-6), intracellular adhesion molecule-1 (ICAM-1), CRP and the insulin sensitivity index (ISI) by hyperinsulinaemic euglycaemic clamp before, 2 days and 2 months after onset of CPAP treatment. RESULTS: Resistin remained unchanged during CPAP-therapy and was negatively correlated to ISI (r=-0.359; p=0.006), the latter was significantly improved by CPAP (p
Keywords: Hormones, Ectopic - blood, Obesity - metabolism, Sleep Apnea, Obstructive - immunology, Body Mass Index, C-Reactive Protein - metabolism, Continuous Positive Airway Pressure, Hormones, Ectopic - blood, Inflammation, Insulin Resistance, Intercellular Adhesion Molecule-1 - blood, Interleukin-6 - blood, Leptin - blood, Obesity - metabolism, Patient Compliance, Polysomnography, Resistin, Sleep Apnea, Obstructive - immunology, Statistics as Topic