Suppression of gastric acid production may improve the course of angina pectoris and the results of treadmill stress test in patients with coronary artery disease
Maciej Świątkowski, Jacek Budzyński, Maria Kłopocka, Grzegorz Pulkowski, Karol Suppan, Jacek Fabisiak, Włodzimierz Morawski, Marcin Majer
Med Sci Monit 2004; 10(9): CR524-529
Available online: 2004-09-01
Background:Juvenile nasopharyngeal angiofibroma (JNA)is a benign neoplasm, which represents less than 0,05%of all head and neck tumours. It affects almost solely adolescent males. Surgery is the main treatment modality. he purpose of this study was to present, based on 24 cases ,typical JNA features on CT and MRI.Material/Methods: We studied 34 patients with stable angina pectoris. In all subjects a medical history, a physical examination, and a stress test were performed at the beginning of the study and after two weeks of add-on rabeprazole therapy (20 mg b.i.d.).Results: Rabeprazole therapy significantly improved the outcome of the stress test in 27 patients (79%), prolonging mean stress exercise time (449±147 vs. 489±156s, p=0.027) and exercise time, leading to a maximum ST interval depression (360±167 vs. 467±148s, p=0.001), and also decreasing ST interval depression delta (1.9±1.1 vs. 1.5±0.9; p=0.013).Conclusions: In 79% of our study subjects, rabeprazole improved stress test results in CAD patients, which implies that at least some of their symptoms were related to GERD. A proton pump inhibitor exerted a favorable effect on the frequency of angina-like chest pain and the results of the treadmill stress test.
Keywords: Angina Pectoris - drug therapy, Benzimidazoles - therapeutic use, Coronary Arteriosclerosis - drug therapy, Gastric Acid - metabolism, Gastroesophageal Reflux - drug therapy, 2-Pyridinylmethylsulfinylbenzimidazoles, Angina Pectoris - drug therapy, Anti-Ulcer Agents - therapeutic use, Benzimidazoles - therapeutic use, Comorbidity, Coronary Artery Disease - physiopathology, Exercise Test, Gastric Acid - metabolism, Gastroesophageal Reflux - drug therapy, Omeprazole - therapeutic use, rabeprazole