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eISSN: 1643-3750

Effect of long-term hemodialysis on plasma lecithin: cholesterol acyltransferase activity and the amounts and compositions of HDL2 and HDL3 in hemodialysis-treated patients with chronic renal failure: a 9-year longitudinal study

Khedidja Mekki, Malika Bouchenak, Mustapha Remaoun, Jacques Belleville

Med Sci Monit 2004; 10(8): CR439-446

ID: 11730

Published: 2004-08-01


Background:Atherosclerosis was correlated with hemodialysis duration (HD) in chronic renal failure (CRF) patients. Dyslipidemias were identified as atherogenic risk factors.Material/Methods: To investigate variations in HDL[sub]2[/sub] and HDL[sub]3[/sub] composition and lecithin: cholesterol acyltransferase (LCAT) activity as functions of HD, 20 CRF patients were selected for maintenance hemodialysis during the 9 years from April 1, 1991 to March 31, 2000. Blood samples were drawn four times: 1991 (T0, study begin), 1994 (T1), 1997 (T2), and 2000 (T3). T0 results were taken as references.Results: Triacylglycerol concentrations were 1.12-fold higher at T1 (P

Keywords: Adult, Cholesterol - blood, Female, Humans, Kidney Failure, Chronic - blood, Kidney Failure, Chronic - therapy, Lipoproteins, HDL - blood, Longitudinal Studies, Male, Middle Aged, Phosphatidylcholine-Sterol O-Acyltransferase - blood, Renal Dialysis - adverse effects, Triglycerides - analysis, Triglycerides - blood, Adult, Cholesterol - blood, Female, Humans, Kidney Failure, Chronic - therapy, Lipoproteins, HDL - blood, Longitudinal Studies, Male, Middle Aged, Phosphatidylcholine-Sterol O-Acyltransferase - blood, Renal Dialysis - adverse effects, Triglycerides - blood



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