02 July 2004
Antibodies against human oxidized low-density lipoprotein (LDL) as markers for human plasma modified lipoproteins
Luminita Radulescu, Camelia Stancu, Felicia AntoheMed Sci Monit 2004; 10(7): BR207-214 :: ID: 11707
Abstract
Background:Recently there has been much interest in the significance and role of antibodies to oxidized LDL (oxLDL) in the plasma of humans and animals with evolving atherosclerosis. The focus in our study was directed on the significance of these antibodies for the pathogenesis and diagnosis of atherosclerosis.
Material/Methods:Antibodies to human in vitro oxidized LDL were generated following the method of Kohler & Milstein and used to detect oxidized LDL in human plasma.Results:Several antibodies to oxLDL were selected for high reactivity against circulating modified LDL. The relationship between antibodies against oxLDL and circulating oxLDL level in human plasma was examined in normal and hyperlipidemic patients. The slight inverse relationship observed between anti-oxLDL antibodies and oxLDL levels in normal patients suggests that anti-oxLDL antibodies have a role in the clearance of oxLDL from circulation.Conclusions:These antibodies can be considered as markers of the pathogenic determinants of atherosclerosis, such as enhanced lipid oxidation, pro-inflammatory stage, and impaired vasodilatation.
Keywords: Angina Pectoris - blood, Antibodies, Monoclonal - chemistry, Antibodies, Monoclonal - immunology, Apolipoprotein A-I - blood, Apolipoproteins B - blood, Autoantibodies - blood, Biological Markers - blood, Blood Glucose - metabolism, Cholesterol - blood, Enzyme-Linked Immunosorbent Assay, Hypertension - blood, Lipoproteins - blood, Lipoproteins, LDL - blood, Lipoproteins, LDL - immunology, Myocardial Ischemia - blood, Spleen - cytology, Triglycerides - blood, Angina Pectoris - blood, Antibodies, Monoclonal - immunology, Apolipoprotein A-I - blood, Apolipoproteins B - blood, Autoantibodies - blood, Biological Markers - blood, Blood Glucose - metabolism, Cholesterol - blood, Enzyme-Linked Immunosorbent Assay, Hypertension - blood, Lipoproteins - blood, Lipoproteins, LDL - immunology, Myocardial Ischemia - blood, Spleen - cytology, Triglycerides - blood
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952