02 July 2004
Pentoxyfilline as a cyclooxygenase (cox-2) inhibitor in experimental sepsis
Bogdan Modzelewski, Adam JaniakMed Sci Monit 2004; 10(7): BR233-237 :: ID: 11697
Abstract
Background:The aim of this study is to assess the impact of pentoxyphilline (PTX) on the pattern of serum concentrations of certain pro-inflammatory cytokines and their soluble receptors in relation to the animal’s survival period.Material/Methods:Diffuse peritonitis was elicited by means of cecal ligation and puncture (CLP) in 45 adult Wistar rats. The pattern of soluble TNF receptor p55 type 1 and p75 type 2 in reference to TNF-α and IL-1β concentration in animals with experimental diffuse peritonitis (EDP) was estimated. All animals were divided into 3 groups.Results:In both groups where animals received medication, the percentage of survival was higher than in the controls. An increase in CRP concentration was observed in all study animals. An increase in TNFa concentration was noted during the first 12 hours of the experiment. There was an increase in soluble TNFR p55 concentrations in all study groups until the 24[sup]th[/sup] hour of the experiment, then a decrease until the end of the observation period. The concentration of soluble TNF p75 receptor gradually increased over time in all groups. In group I a constant rise of IL-1b serum concentration was observed.Conclusions:Pentoxyphilline administration in animals in the early stage of diffuse peritonitis causes the TNFα serum concentration to decrease, but it does not improve the overall survival period. Late pentoxyphilline administration does not alter the course of diffuse peritonitis in rat.
Keywords: Antigens, CD - blood, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors - pharmacology, Injections, Intraperitoneal, Interleukin-1 - blood, Isoenzymes - antagonists & inhibitors, Pentoxifylline - pharmacology, Peritonitis - complications, Peritonitis - enzymology, Peritonitis - etiology, Peritonitis - immunology, Prostaglandin-Endoperoxide Synthases, Rats, Wistar, Receptors, Tumor Necrosis Factor - blood, Receptors, Tumor Necrosis Factor, Type I, Sepsis - drug therapy, Sepsis - enzymology, Sepsis - immunology, Time Factors, Tumor Necrosis Factor-alpha - analysis, Antigens, CD - blood, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors - pharmacology, Injections, Intraperitoneal, Interleukin-1 - blood, Isoenzymes - antagonists & inhibitors, Pentoxifylline - pharmacology, Peritonitis - immunology, Prostaglandin-Endoperoxide Synthases, Rats, Wistar, Receptors, Tumor Necrosis Factor - blood, Receptors, Tumor Necrosis Factor, Type I, Sepsis - immunology, Time Factors, Tumor Necrosis Factor-alpha - analysis
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Effects of Thermal Insulation on Recovery and Comfort of Patients Undergoing Holmium Laser LithotripsyMed Sci Monit In Press; DOI: 10.12659/MSM.942836
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952