01 April 2004
Med Sci Monit 2004; 10(4): BR96-104 :: ID: 11626
Background: In BALB/c mice, a yogurt diet given before and after the carcinogen 1, 2 dymethylhydrazine
(DMH) inhibited colon cancer. This paper studied at which stage of tumor development (initiation, promotion or progression) yogurt exerts its antitumor activity.
Material/Methods: Six experimental groups were used: 1) non-treatment control; 2) DMH control; 3) yogurt-
DMH-yogurt: yogurt administered before and after DMH. 4) yogurt-DMH: yogurt given only
10 days before DMH; 5) DMH-yogurt: yogurt given cyclically after DMH; and 6) yogurt control. The groups DMH-yogurt and yogurt-DMH were compared histologically and TNFα, INFγ, IL-10 and IL-4 cytokines, CD4[sup]+[/sup]/CD25[sup]+[/sup] T cells, and apoptotic cells were determined in large intestine biopsies. TNFα and INFγ were also determined in cells isolated from large
intestine nodules and from Peyer’s patches.
Results: The DMH-yogurt group did not develop tumor. The yogurt-DMH group showed only tumor
delay; TNFα, INFγ and IL-10 increasing in this group in all the periods assayed. These results agree with those already reported for DMH control and yogurt-DMH-yogurt. There was no correlation between the high levels of IL-10 and CD4[sup]+[/sup]/CD25+ T regulatory population. IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months. In the DMHyogurt group, cellular apoptosis increased during the whole treatment. Yogurt feeding
induced TNFα and INFγ increases in cells isolated from large intestine nodules. These cytokines also increased in cells from Peyer’s patches of the yogurt control group.
Conclusions: These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis.
Keywords: 1,2-Dimethylhydrazine - toxicity, Animals, Antigens, CD4 - immunology, Apoptosis - physiology, Carcinogens - toxicity, Colorectal Neoplasms - chemically induced, Colorectal Neoplasms - diet therapy, Cytokines - metabolism, Intestines - immunology, Intestines - pathology, Mice, Mice, Inbred BALB C, Peyer's Patches - immunology, Peyer's Patches - pathology, Receptors, Interleukin-2 - immunology, T-Lymphocytes - cytology, T-Lymphocytes - immunology, Yogurt - microbiology, 1,2-Dimethylhydrazine - toxicity, Animals, Antigens, CD4 - immunology, Apoptosis - physiology, Carcinogens - toxicity, Colorectal Neoplasms - diet therapy, Cytokines - metabolism, Intestines - pathology, Mice, Mice, Inbred BALB C, Peyer's Patches - pathology, Receptors, Interleukin-2 - immunology, T-Lymphocytes - immunology, Yogurt - microbiology
This Week Editorial
20 September 2021 : EditorialEditorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19
Med Sci Monit 2021; 27:e934766
22 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...
Med Sci Monit In Press; DOI: 10.12659/MSM.934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
24 Sep 2021 : Database AnalysisA Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors
Med Sci Monit In Press; DOI: 10.12659/MSM.933559
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700