Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 February 2004

Pregnancy complications and perinatal outcome in diabetic women treated with Humalog (insulin lispro) or regular human insulin during pregnancy

Katarzyna Cypryk, Małgorzata Sobczak, Magdalena Pertyńska-Marczewska, Małgorzata Zawodniak-Szałapska, Wiesław Szymczak, Jan Wilczyński, Andrzej Lewiński

Med Sci Monit 2004; 10(2): PI29-32 :: ID: 11591

Abstract

Background: Pregnancy outcome in diabetic women is strictly related to glycemic control during pregnancy. The aim of our study was to compare pregnancy outcome between patients subjected to intensive insulin therapy using regular human insulin and those treated with insulin lispro (Humalog).
Material/Methods: Group A (n=25) was treated with Humalog, and the control group B (n=46) with regular human insulin. Mean age, duration of diabetes, presence of chronic diabetic complications (according to the White classification) parity, and BMI did not differ between groups.
Results: The mean HbA1c concentrations in groups A and B were respectively: 7.8±1.4% vs. 7.5±1.5% in the first trimester, 6.4±0.8% vs. 6.5±1.6% in the second, and 6.7±0.7% vs. 6.3±1.2% in the third (no significant differences). The duration of pregnancy was 36.4±3.9 weeks in group A and 37.1±1.9 weeks in group B, while the mean neonatal birth weight was 3467±790 and 3367±666 g, respectively. Neither the frequency of preterm labor and cesarean section nor the frequency of fetal macrosomia and hypoglycemia differed between groups. There was only one malformed infant in the human insulin-treated group, and no statistical difference in the rate of spontaneous abortion between groups. Also, there were no differences in the frequencies of occurrence of hypertension (essential and pregnancy induced) and urinary tract infections.
Conclusions: The course of pregnancy and perinatal outcome is comparable in intensively treated diabetic women regardless of the short-acting insulin used. ‘Humalog’ appears to be a safe alternative to human insulin in the treatment of diabetes during pregnancy.

Keywords: Adult, Apgar Score, Diabetes Mellitus, Type 1 - blood, Diabetes Mellitus, Type 1 - drug therapy, Gravidity, Hemoglobin A, Glycosylated - analysis, Hypoglycemia - epidemiology, Hypoglycemia - metabolism, Hypoglycemic Agents - administration & dosage, Infant, Newborn, Insulin - administration & dosage, Insulin - analogs & derivatives, Perinatal Care, Pregnancy, Pregnancy Outcome, Pregnancy Trimesters - blood, Pregnancy in Diabetics - blood, Pregnancy in Diabetics - drug therapy, Adult, Apgar Score, Diabetes Mellitus, Type 1 - drug therapy, Gravidity, Hemoglobin A, Glycosylated - analysis, Hypoglycemia - metabolism, Hypoglycemic Agents - administration & dosage, Infant, Newborn, Insulin - analogs & derivatives, Insulin Lispro, Perinatal Care, Pregnancy, Pregnancy Outcome, Pregnancy Trimesters - blood, Pregnancy in Diabetics - drug therapy

0 Comments

Weekly Editorial

27 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934854

Med Sci Monit 2021; 27:e934854

SARS-CoV-2/COVID-19

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

27 Sep 2021 : Clinical Research

Effect of Combined Thoracic Paravertebral Block and General Anesthesia vs General Anesthesia Alone on Posto...

Med Sci Monit In Press; DOI: 10.12659/MSM.933623  

24 Sep 2021 : Clinical Research

A Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...

Med Sci Monit In Press; DOI: 10.12659/MSM.933809  

24 Sep 2021 : Database Analysis

Relationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)

Med Sci Monit In Press; DOI: 10.12659/MSM.933448  

24 Sep 2021 : Database Analysis

A Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors

Med Sci Monit In Press; DOI: 10.12659/MSM.933559  

Most Viewed Current Articles

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750