Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 February 2004

The effect of hormone replacement therapy on endothelial function in postmenopausal women with hypertension

Danuta Czarnecka, Kalina Kawecka-Jaszcz, Agnieszka Olszanecka, Aldona Dembińska-Kieć, Małgorzata Malczewska-Malec, Anna Zdzienicka, Ibeth Guevara

Med Sci Monit 2004; 10(2): CR55-61 :: ID: 11576

Abstract

Background:Endothelial dysfunction has been implicated in the pathophysiology of cardiovascular diseases, including arterial hypertension. The present study was undertaken to assess endothelial function in postmenopausal women with arterial hypertension receiving hormone replacement therapy and antihypertensive treatment.Material/Methods: A group of 76 women with natural menopause and essential mild to moderate arterial hypertension entered the study. Forty women received a transdermal, combined hormone replacement therapy (HRT) of 17ß-estradiol and norethisterone acetate, whereas 36 served as controls. At baseline and at 3 and 12 months, all patients underwent 24-hr blood pressure monitoring and an exercise test, before which, at peak exercise, and after a 15-min recovery period venous blood was drawn to measure the level of nitrite/nitrate (NOx) according to the Griess method.Results: At 3 and 12 months after beginning HRT, the level of NOx at rest was slightly increased, with marked individual differences in response to HRT. In women not receiving HRT, NOx did not change. In the HRT group, 52.5% at 3 months and 47.5% at 12 months had significantly increased levels compared with the baseline values (17.8±6.7 vs. 32.8±4.5 vs. 28.7±1.1 Kmol/l; p=0.002). The increased NOx level in responders was associated with decreased LDL cholesterol (3.62±1.2 vs. 3.53±1.3 vs. 2.6±0.6 mmol/l; p=0.01). At 12 months, blood pressure values did not differ from those at baseline in either group.Conclusions: The significant increase of NOx in half of the women receiving HRT suggests that only responders experience the cardioprotective effects of HRT.

Keywords: Administration, Cutaneous, Antihypertensive Agents - therapeutic use, Blood Pressure - drug effects, Blood Pressure - physiology, Blood Pressure Monitoring, Ambulatory, Cholesterol, LDL - blood, Drug Combinations, Endothelium, Vascular - drug effects, Endothelium, Vascular - physiology, Estradiol - administration & dosage, Estradiol - blood, Estradiol - pharmacology, Follicle Stimulating Hormone - blood, Follow-Up Studies, Hormone Replacement Therapy, Hypertension - drug therapy, Hypertension - physiopathology, Nitric Oxide - blood, Nitrites - blood, Norethindrone - administration & dosage, Norethindrone - pharmacology, Postmenopause - drug effects, Postmenopause - physiology, Time Factors, Administration, Cutaneous, Antihypertensive Agents - therapeutic use, Blood Pressure - physiology, Blood Pressure Monitoring, Ambulatory, Cholesterol, LDL - blood, Drug Combinations, Endothelium, Vascular - physiology, Estradiol - pharmacology, Follicle Stimulating Hormone - blood, Follow-Up Studies, Hormone Replacement Therapy, Hypertension - physiopathology, Nitric Oxide - blood, Nitrites - blood, Norethindrone - pharmacology, Postmenopause - physiology, Time Factors

Comments

Editorial

01 May 2022 : Editorial  

Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937048

Med Sci Monit 2022; 28:e937048

SARS-CoV-2/COVID-19

04 May 2022 : Clinical Research  

Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936069  

22 April 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit In Press; DOI: 10.12659/MSM.936547  

27 April 2022 : Meta-Analysis  

Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review...

Med Sci Monit In Press; DOI: 10.12659/MSM.935823  

06 May 2022 : Clinical Research  

COVID-19: Another Cause of Dental Anxiety?

Med Sci Monit 2022; 28:e936535

In Press

19 May 2022 : Clinical Research  

Association Between Serum Homocysteine Levels and Severity of Diabetic Kidney Disease in 489 Patients with ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936323  

18 May 2022 : Clinical Research  

Physical and Psychosocial Concept Domains Related to Health-Related Quality of Life (HRQL) in 50 Girls and ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936801  

18 May 2022 : Clinical Research  

Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Haina...

Med Sci Monit In Press; DOI: 10.12659/MSM.936134  

17 May 2022 : Clinical Research  

Clinical Application of C-TIRADS Category and Contrast-Enhanced Ultrasound in Differential Diagnosis of Sol...

Med Sci Monit In Press; DOI: 10.12659/MSM.936368  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750