01 February 2004
The effect of hormone replacement therapy on endothelial function in postmenopausal women with hypertensionDanuta Czarnecka, Kalina Kawecka-Jaszcz, Agnieszka Olszanecka, Aldona Dembińska-Kieć, Małgorzata Malczewska-Malec, Anna Zdzienicka, Ibeth Guevara
Med Sci Monit 2004; 10(2): CR55-61 :: ID: 11576
Background:Endothelial dysfunction has been implicated in the pathophysiology of cardiovascular diseases, including arterial hypertension. The present study was undertaken to assess endothelial function in postmenopausal women with arterial hypertension receiving hormone replacement therapy and antihypertensive treatment.Material/Methods: A group of 76 women with natural menopause and essential mild to moderate arterial hypertension entered the study. Forty women received a transdermal, combined hormone replacement therapy (HRT) of 17ß-estradiol and norethisterone acetate, whereas 36 served as controls. At baseline and at 3 and 12 months, all patients underwent 24-hr blood pressure monitoring and an exercise test, before which, at peak exercise, and after a 15-min recovery period venous blood was drawn to measure the level of nitrite/nitrate (NOx) according to the Griess method.Results: At 3 and 12 months after beginning HRT, the level of NOx at rest was slightly increased, with marked individual differences in response to HRT. In women not receiving HRT, NOx did not change. In the HRT group, 52.5% at 3 months and 47.5% at 12 months had significantly increased levels compared with the baseline values (17.8±6.7 vs. 32.8±4.5 vs. 28.7±1.1 Kmol/l; p=0.002). The increased NOx level in responders was associated with decreased LDL cholesterol (3.62±1.2 vs. 3.53±1.3 vs. 2.6±0.6 mmol/l; p=0.01). At 12 months, blood pressure values did not differ from those at baseline in either group.Conclusions: The significant increase of NOx in half of the women receiving HRT suggests that only responders experience the cardioprotective effects of HRT.
Keywords: Administration, Cutaneous, Antihypertensive Agents - therapeutic use, Blood Pressure - drug effects, Blood Pressure - physiology, Blood Pressure Monitoring, Ambulatory, Cholesterol, LDL - blood, Drug Combinations, Endothelium, Vascular - drug effects, Endothelium, Vascular - physiology, Estradiol - administration & dosage, Estradiol - blood, Estradiol - pharmacology, Follicle Stimulating Hormone - blood, Follow-Up Studies, Hormone Replacement Therapy, Hypertension - drug therapy, Hypertension - physiopathology, Nitric Oxide - blood, Nitrites - blood, Norethindrone - administration & dosage, Norethindrone - pharmacology, Postmenopause - drug effects, Postmenopause - physiology, Time Factors, Administration, Cutaneous, Antihypertensive Agents - therapeutic use, Blood Pressure - physiology, Blood Pressure Monitoring, Ambulatory, Cholesterol, LDL - blood, Drug Combinations, Endothelium, Vascular - physiology, Estradiol - pharmacology, Follicle Stimulating Hormone - blood, Follow-Up Studies, Hormone Replacement Therapy, Hypertension - physiopathology, Nitric Oxide - blood, Nitrites - blood, Norethindrone - pharmacology, Postmenopause - physiology, Time Factors
This Week Editorial
20 September 2021 : EditorialEditorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19
Med Sci Monit 2021; 27:e934766
22 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...
Med Sci Monit In Press; DOI: 10.12659/MSM.934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
24 Sep 2021 : Database AnalysisA Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors
Med Sci Monit In Press; DOI: 10.12659/MSM.933559
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700