20 September 2021: Editorial
Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19Dinah V. Parums *
Med Sci Monit 2021; 27:e934766
ABSTRACT: During the past two years, clinical studies have attempted to identify risk factors to predict clinical outcomes following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In July 2021, a study using a high-throughput technique detected autoantibodies to chemokines, cytokines, and complement components in patients with symptomatic coronavirus disease 2019 (COVID-19). In August 2021, a study identified pre-existing autoantibodies to type 1 interferons (IFNs) in 10% of patients with severe COVID-19 but not asymptomatic individuals. Autoantibodies may be the long-awaited markers of clinical risk for severe COVID-19 in patients with SARS-CoV-2 infection. This Editorial aims to present some recent findings of autoantibodies to components of the immune system, including type 1 IFNs, and the risk of severe COVID-19.
Keywords: Editorial, Autoantibodies, Interferons, Risk, severe acute respiratory syndrome coronavirus 2, COVID-19
Ongoing studies have identified a possible role for autoantibodies in the development of clinically severe COVID-19. It is possible that autoantibodies to components of the immune system, which are either pre-existing or develop after infection, impair immune control of SARS-CoV-2. The role of autoantibodies to components of the immune system in the pathogenesis of COVID-19 may involve inhibition of immunoreceptor signaling or directly affect immune cells. There is the possibility that newly identified autoantibodies may be the long-awaited markers for clinical risk of severe COVID-19 in patients with SARS-CoV-2 infection.
1. Grasselli G, Greco M, Zanella A: Risk factors associated with mortality among patients with COVID-19 in Intensive Care Units in Lombardy, Italy: JAMA Intern Med, 2020; 180(10); 1345-55
2. Costagliola G, Spada E, Consolini R: Age-related differences in the immune response could contribute to determine the spectrum of severity of COVID-19: Immun Inflamm Dis, 2021; 9(2); 331-39
3. Sandoval M, Nguyen DT, Vahidy FS, Graviss EA: Risk factors for severity of COVID-19 in hospital patients age 18–29 years: PLoS One, 2021; 16(7); e0255544
4. Wu Z, McGoogan JM: Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention: JAMA, 2020; 323; 1239-42
5. Bennett TD, Moffitt RA, Hajagos JG: Clinical characterization and prediction of clinical severity of SARS-CoV-2 infection among US adults using data from the US National COVID Cohort Collaborative: JAMA Netw Open, 2021; 4(7); e2116901
6. Miller IF, Becker AD, Grenfell BT, Metcalf CJE: Disease and healthcare burden of COVID-19 in the United States: Nat Med, 2020; 26(8); 1212-17
7. Wang EY, Mao T, Klein J: Diverse functional autoantibodies in patients with COVID-19: Nature, 2021; 595(7866); 283-88
8. Bastard P, Gervais A, Le Voyer T: Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths: Sci Immunol, 2021; 6(62); eabl4340
9. Bastard P, Rosen LB, Zhang Q: Autoantibodies against type I IFNs in patients with life-threatening COVID-19: Science, 2020; 370(6515); eabd4585
10. Zhang Q, Bastard P, Liu Z: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19: Science, 2020; 370(6515); eabd4570
11. Asano T, Boisson B, Onodi F: X-linked recessive TLR7 deficiency in ~10f men under 60 years old with life-threatening COVID-19: Sci Immunol, 2021; 6(62)
12. McNab F, Mayer-Barber K, Sher A: Type I interferons in infectious disease: Nat Rev Immunol, 2015; 15(2); 87-103
13 October 2021 : EditorialEditorial: Global Initiatives Support the Use and Regulation of Digital Health Technology During the COVID-...
Med Sci Monit In Press; DOI: 10.12659/MSM.935123
11 October 2021 : Clinical ResearchClinical Features and Temporal Lung Radiographic Changes in 25 Patients Recovering from COVID-19 Pneumonia:...
Med Sci Monit In Press; DOI: 10.12659/MSM.933381
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
13 Oct 2021 : EditorialEditorial: Global Initiatives Support the Use and Regulation of Digital Health Technology During the COVID-...
Med Sci Monit In Press; DOI: 10.12659/MSM.935123
13 Oct 2021 : Clinical ResearchEndovascular Repair of Thoracic Aorta Injury: 17 Years of Single-Center Experience
Med Sci Monit In Press; DOI: 10.12659/MSM.934479
11 Oct 2021 : Clinical ResearchChallenges for Polish Community Pharmacists in Provision of Services to Immigrants and Non-Polish-Speakers ...
Med Sci Monit In Press; DOI: 10.12659/MSM.933678
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700