Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

02 August 2021: Editorial

Editorial: The National COVID Cohort Collaborative Consortium Combines Population Data with Machine Learning to Evaluate and Predict Risk Factors for the Severity of COVID-19

Dinah V. Parums *

DOI: 10.12659/MSM.934171

Med Sci Monit 2021; 27:e934171


ABSTRACT: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) commonly presents with pneumonia. However, COVID-19 is now recognized to involve multiple organ systems with varying severity and duration. In July 2021, the findings from a retrospective population study from the National COVID Cohort Collaborative (N3C) Consortium were published that included analysis by machine learning methods of 174,568 adults with SARS-CoV-2 infection from 34 medical centers in the US. The study stratified patients for COVID-19 according to the World Health Organization (WHO) Clinical Progression Scale (CPS). Severe clinical outcomes were identified as the requirement for invasive ventilatory support, or extracorporeal membrane oxygenation (ECMO), and patient mortality. Machine learning analysis showed that the factor most strongly associated with severity of clinical course in patients with COVID-19 was pH. A separate multivariable logistic regression model showed that independent factors associated with more severe clinical outcomes included age, dementia, male gender, liver disease, and obesity. This Editorial aims to present the rationale and findings of the largest population cohort of adult patients with COVID-19 to date and highlights the importance of using large population studies with sophisticated analytical methods, including machine learning.

Keywords: Editorial, Population Characteristics, machine learning, Epidemiology, severe acute respiratory syndrome, COVID-19, severe acute respiratory syndrome coronavirus 2


Machine learning analysis of a national multicenter population database from the US the National COVID Cohort Collaborative (N3C) Consortium analyzed clinical and demographic data on 174,568 SARS-CoV-2-positive adults admitted to hospital. This study confirmed that patient mortality from COVID-19 decreased during 2020. Patient demographic characteristics of age, male gender, and comorbidities, including obesity, were associated with increased clinical severity.


1. Parums DV: Editorial: Long COVID, or post-COVID syndrome, and the global impact on health care: Med Sci Monit, 2021; 27; e933446

2. Li L, Sun W, Han M: A study on the predictors of disease severity of COVID-19: Med Sci Monit, 2020; 26; e927167

3. Hochhegger B, Zanon M, Altmayer S: COVID-19 mimics on chest CT: A pictorial review and radiologic guide: Br J Radiol, 2021; 94(1118); 20200703

4. Collins J, Stern EJ: Ground-glass opacity at CT: The ABCs: Am J Roentgenol, 1997; 169; 355-67

5. Collins J, Stern EJ: COVID-19 Treatment Guidelines Panel: Clinical spectrum of SARS-CoV-2 infection, 2021

6. Collins J, Stern EJ: A minimal common outcome measure set for COVID-19 clinical research: Lancet Infect Dis, 2020; 20(8); e192-97

7. Wang Y, Yao S, Liu X: Risk factors of coronavirus disease 2019-related mortality and optimal treatment regimens: A retrospective study: Med Sci Monit, 2021; 27; e926751

8. Parums DV: Editorial: Registries and population databases in clinical research and practice: Med Sci Monit, 2021; 27; e933554

9. Parums DV: Editorial: Artificial intelligence (AI) in clinical medicine and the 2020 CONSORT-AI study guidelines: Med Sci Monit, 2021; 27; e933675

10. Bennett TD, Moffitt RA, Hajagos JG: Clinical characterization and prediction of clinical severity of SARS-CoV-2 infection among US adults using data from the US National COVID Cohort Collaborative: JAMA Netw Open, 2021; 4(7); e2116901

11. Haendel MA, Chute CG, Bennett TD: The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment: J Am Med Inform Assoc, 2021; 28(3); 427-43

Coronavirus/Covid 19

22 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

24 Sep 2021 : Clinical Research

A Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...

Med Sci Monit In Press; DOI: 10.12659/MSM.933809  

24 Sep 2021 : Database Analysis

Relationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)

Med Sci Monit In Press; DOI: 10.12659/MSM.933448  

24 Sep 2021 : Database Analysis

A Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors

Med Sci Monit In Press; DOI: 10.12659/MSM.933559  

24 Sep 2021 : Clinical Research

Value of Ocular Endoscopy in Extraction of Intraocular Foreign Bodies of Cilia in Patients with Open Ocular...

Med Sci Monit In Press; DOI: 10.12659/MSM.932970  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750