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05 July 2021: Editorial

Editorial: Maternal SARS-CoV-2 Infection and Pregnancy Outcomes from Current Global Study Data

Dinah V. Parums *

DOI: 10.12659/MSM.933831

Med Sci Monit 2021; 27:e933831

Abstract

ABSTRACT: During the global COVID-19 pandemic, data from clinical studies, systematic review, and population registry data have shown that when compared with non-pregnant women, SARS-CoV-2 infection in pregnancy is associated with a small increase in risk to the mother. Large cohort studies and registry data collected from 2020 have included the US Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET), COVI-PREG, the UK and Global Pregnancy and Neonatal Outcomes in COVID-19 (PAN-COVID) study, the American Academy of Pediatrics (AAP) Section on Neonatal-Perinatal Medicine (SONPM) National Perinatal COVID-19 Registry, the Swedish Pregnancy Register, and the Canadian Surveillance of COVID-19 in Pregnancy (CANCOVID-Preg) registry. Recently published data have shown that most maternal infections with SARS-CoV-2 occur during the third trimester and result in a small increase in hospital admission, admission to the intensive care unit (ICU), mechanical ventilation, preterm birth, and increased cesarean sections in mothers infected with SARS-CoV-2. However, currently approved vaccines given in pregnancy result in an immune response to current SARS-CoV-2 variants. Transplacental transmission of SARS-CoV-2 to the fetus can occur, but the immediate and long-term effects on the newborn infant remain unclear. Therefore, women who are pregnant or planning a pregnancy should be managed according to current clinical guidelines with timely vaccination to prevent infection with SARS-CoV-2. This Editorial summarizes what is currently known about maternal SARS-CoV-2 infection and pregnancy outcomes from multinational studies.

Keywords: Editorial, COVID-19, Treatment Outcome

Conclusions

Data from clinical studies, systematic review, and population registry data have shown a small increase in risk to the mother from SARS-CoV-2 infection. Transplacental transmission of SARS-CoV-2 from the mother to the fetus can occur, but the immediate and long-term effects on the newborn infant remain unclear. The increased risk of hospitalization and ICU admission in pregnant women infected with SARS-CoV-2 may be due to the immunosuppressive effects of pregnancy or increased caution by healthcare providers during the COVID-19 pandemic. Women who are pregnant or planning a pregnancy should be managed according to current clinical guidelines with timely vaccination to prevent infection with SARS-CoV-2.

References

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750