Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

17 May 2021: Editorial

Editorial: mRNA Vaccines and Immunotherapy in Oncology: A New Era for Personalized Medicine

Dinah V. Parums *

DOI: 10.12659/MSM.933088

Med Sci Monit 2021; 27:e933088


ABSTRACT: Synthetic mRNA and the expression of therapeutic proteins have accelerated vaccine development to prevent infection and heralds a new era in targeted immunotherapy in oncology. Therapeutic mRNA vaccines rely on available tumor tissue for gene sequencing analysis to compare the patient’s normal cellular DNA sequences and those of the tumor. Carrier-based mRNA vaccines for cancer immunotherapy are now in development that use delivery systems based on peptides, lipids, polymers, and cationic nano-emulsions. There have also been recent developments in dendritic cell-based mRNA vaccines. For patients with available tumor tissue samples, it is possible to develop mRNA vaccines that result in the expression of tumor antigens by antigen-presenting cells (APCs), resulting in innate and adaptive immune responses. Ongoing developments in mRNA immunotherapy include modifications in the route of administration and combined delivery of multiple mRNA vaccines with checkpoint inhibitors. This Editorial aims to present a brief overview of how mRNA immunotherapy may change the therapeutic landscape of personalized medicine for patients with solid malignant tumors.

Keywords: Editorial, targeted therapy, oncology, vaccine, mRNA, Immunotherapy, personalized medicine


In oncology, mRNA vaccines for immunotherapy have undergone accelerated clinical development following regulatory approvals of mRNA vaccines to SARS-CoV-2. Because mRNA vaccines for personalized oncology immunotherapy rely on tumor tissue for gene sequencing, it is anticipated that laboratory molecular diagnostics will undergo rapid development and authorization for routine use to support a new era for personalized medicine.


1. Jia L, Mao Y, Ji Q: Decoding mRNA translatability and stability from the 5′ UTR: Nat Struct Mol Biol, 2020; 27(9); 814-21

2. Paston SJ, Brentville VA, Symonds P, Durrant LG: Cancer vaccines, adjuvants, and delivery systems: Front Immunol, 2021; 12; 627932

3. Miao L, Zhang Y, Huang L: mRNA vaccine for cancer immunotherapy: Mol Cancer, 2021; 20(1); 41

4. Wang Y, Zhang Z, Luo J: mRNA vaccine: A potential therapeutic strategy: Mol Cancer, 2021; 20(1); 33

5. Kim J, Eygeris Y, Gupta M, Sahay G: Self-assembled mRNA vaccines: Adv Drug Deliv Rev, 2021; 170; 83-112

6. Dolgin E: How COVID unlocked the power of RNA vaccines: Nature, 2021; 589(7841); 189-91

7. Wang F, Kream RM, Stefano GB: An evidence based perspective on mRNA-SARS-CoV-2 vaccine development: Med Sci Monit, 2020; 26; e924700

8. Parums DV: Editorial: mRNA Vaccines and Future Epidemic, Pandemic, and Endemic Zoonotic Virus Infections: Med Sci Monit, 2021; 27; e932915

9. Parums DV:: mRNA Personalized Cancer Vaccines and Immuno-Oncology, 2021

10. Parums DV:: Individualized Cancer Medicine, 2021

11. Bauman J, Burns H, Clarke J: 798 Safety, tolerability, and immunogenicity of mRNA-4157 in combination with pembrolizumab in subjects with unresectable solid tumors (KEYNOTE-603): An update: J Immunother Cancer, 2020; 8(Suppl 3); A477

12. Sahin U, Oehm P, Derhovanessian E: An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma: Nature, 2020; 585(7823); 107-12

13. Beck JD, Reidenbach D, Salomon N: mRNA therapeutics in cancer immunotherapy: Mol Cancer, 2021; 20(1); 69

Coronavirus/Covid 19

22 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

22 Sep 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

22 Sep 2021 : Clinical Research

A Comparative Study of the Clinical Efficacy and Safety of Pneumatic Trabeculoplasty and Selective Laser Tr...

Med Sci Monit In Press; DOI: 10.12659/MSM.933454  

20 Sep 2021 : Clinical Research

Comparison of the Use of Magnetic Resonance Imaging of Partial Anterior Cruciate Ligament Tears Using Maxim...

Med Sci Monit In Press; DOI: 10.12659/MSM.932228  

20 Sep 2021 : Clinical Research

Automated Boluses and Delayed-Start Timers Prolong Perineural Local Anesthetic Infusions and Analgesia Foll...

Med Sci Monit In Press; DOI: 10.12659/MSM.933190  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750