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14 May 2021: Clinical Research

Recognizing Early Regulation Disorders in Pediatric Care: The For Healthy Offspring Project

Noémi Scheuring 1ABCDEFG , Ildikó Danis 2ABCDEF , Eszter Papp 1BDEF , Pálma Benedek 3BDEF , Tünde Németh 4BDEF , Ágnes Gulácsi 1BCDEF , László Szabó 15ABCDEF*

DOI: 10.12659/MSM.930214

Med Sci Monit 2021; 27:e930214


BACKGROUND: Regulation disorders are already apparent in infancy. The For Healthy Offspring Project was the first Hungarian study aimed at building an effective model for screening and examining the prevalence and complex (medical and psychosocial) background of classic behavior regulation disorders (excessive crying, feeding, and sleep problems) in infancy.

MATERIAL AND METHODS: Data were collected from families of 0- to 3-year-old children in a pediatric hospital and its neighboring areas through questionnaires, medical examinations, and individual and small-group consultations.

RESULTS: In the questionnaire study about their children’s behavior (n=1133), 15% of mothers reported excessive crying, 16% reported feeding problems, and 10% reported sleep problems. In a subsample (n=619) in which medical examinations were also conducted, the prevalence of medical diagnoses was 15.0% for excessive crying, 15.2% for sleep disorders, 10.3% for breastfeeding difficulties, and 14.8% for feeding disorders. Children who were referred to the screening program (n=183) had significantly more behavior regulation disorders than the other children in our study. Regulation disorders were found to be comorbid with other health conditions in some cases.

CONCLUSIONS: We developed a complex model to screen for regulatory problems in early childhood. This study adds more information about the relationship between regulation problems and other health conditions. The general incidence (5-15%) of early childhood regulation disorders in other countries is likely similar to that found in Hungary. In order to effectively recognize early regulation disorders, diagnostic instruments widely used in the international field should be adapted in general Hungarian pediatric care.

Keywords: Crying, Feeding Behavior, Infant Behavior, Sleep Disorders


Emotional and behavior regulation disorders in infancy and toddlerhood are quite frequent, with an occurrence of 5–20% in a normal population [1–5]. Primary or classic regulation disorders (“the classic triad”), such as excessive and persistent crying and sleep and feeding disorders, are already seen in early infancy and can also be recognized and diagnosed in primary care [1,6–10]. According to the framework of developmental psychopathology [11], in most cases, the cumulative combination of somatic, interactional, and psychosocial environmental risk factors and a lack of significant protective factors leads to problematic behaviors associated with several types of early mental health problems [10]. Similar to other early childhood mental health problems, the background of regulation disorders is also assumed to be influenced by complex mechanisms, whereby the individual physical and psychological characteristics of the parents and the children, their common early history (pregnancy, birth, early care), the actual parent-child interactions, and the developing relationships serve as key proximal mediators of more complex distal factors, such as the sociodemographic situation, family structure, stressful life events, and social support. Naturally, the manifestation of certain problems can depend on other moderating factors, such as the age, sex, and temperament of the child [1,12].

This clinical area is specifically located at the juncture of medicine, psychology, and education, and it therefore requires an interdisciplinary approach and handling. The risk factors that compromise childhood development, parent-child interactions, and family functioning and the protective factors that support resilient development are important issues to be borne in mind in both research and clinical practice [13]. Since most of the relevant literature comes from small-sample studies, continued research is needed with larger samples to further explore the clinical significance of regulation disorders [14]. In the meantime, the findings as a whole highlight the paucity of evidence about this group of infants and the need to prioritize them for research and clinical work [15].

The study, screening, and treatment of early childhood mental health problems have a decades-long history in international practice, but the investigation of such disorders, as well as the related prevention and intervention activities, remains an understudied area in Hungary. To date, only a few national private and public initiatives have expressed interest in developing this area. The For Healthy Offspring Project, initiated by the Heim Pál National Pediatric Institute in Budapest, was the first Hungarian research to establish an effective hospital model for screening and to examine the prevalence of emotional and behavior regulation disorders in early childhood (0–3 years) and the significance of different risks and protective factors behind them. We hypothesized that the prevalence of regulation disorders in Hungary is similar to that in other countries. We also hypothesized that the association between excessive crying and sleep disorders is strong. We developed a complex model to screen for regulatory problems in early childhood.

In this article, our aims were to (1) introduce the model of our screening program and our large-sample hospital research, (2) report the occurrence of major regulation disorders (excessive crying, sleep and feeding problems) in our sample, and (3) report associations between regulation disorders and other examined medical diseases.

We hypothesized that (1) the prevalence of regulation disorders in our Hungarian sample is similar to that of other countries, (2) the associations between excessive crying, sleep and feeding disorders are significant, and (3) these regulation problems may also be moderately associated with other diseases.

Material and Methods

The Screening Program: Diagnostic Evaluation


Medical consultation (performed by NS and EP) consisted of a focused, detailed history taking that was followed by a physical examination. During the physical examination, healthy somatic, motor, and psychosocial developmental signs were carefully considered. In most cases, both parents were present when the child was examined; however, in a few cases, only the mother was present. The consultation normally lasted 1 h.

History taking started with the discussion of the symptom(s) that the parents had concerns about, and it was followed by general pediatric questions. To obtain broader knowledge of circumstances, certain aspects of the child’s psychiatric history (birth circumstances, pregnancy, perinatal period, early sensory-motor and mental development, family sociodemographic characteristics) were also included. In all cases, the primary consideration was to determine the organic causes of the symptoms. If no physical abnormalities were found, we assumed the causative effect of psychosocial factors.


The results of the first consultation determined the subsequent diagnostic steps. Diagnostic evaluation of the organic causes was performed depending on the presence of abnormal findings. Examinations were performed at the Pediatric Department as an outpatient service and included laboratory tests and radiological imaging tests. In some cases, specific examinations were performed by a gastroenterologist, neurologist, otorhinolaryngologist, ophthalmologist, or cardiologist. An obstructive sleep apnea symptoms test and, in cases of indeterminate symptoms of the infant or the presence of apnea, polysomnographic monitoring combined with esophageal pH monitoring was performed (by PB) at the Sleep Ambulance by Somnoscreen Plus (SOMNOmedics, GmbH, Randersacker, Germany). The following symptoms of unspecified/unexplained origin, usually with no underlying medical condition, were found: periodic breath-holding spells or strange breathing sounds, change of skin tone, loss of consciousness, loss of postural tone, and seizure. A complex motor evaluation of the infant was completed by a physiotherapist.

In cases of medical illness, our work was based on general pediatric diagnostic steps. We had more difficulty diagnosing early behavior regulation disorders. The International Classification of Diseases, 10th Revision (ICD-10) [16], which is used in Hungary, does not include clear directions about early childhood regulation disorders. In the differential diagnostics of regulation disorders, we relied on the principles of the German system, as described by Hédervári-Heller [17] in Hungarian and German, although it is not widely used in Hungary. Moreover, we greatly profited from reviewing the classification criteria of the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood – Revised (DC: 0–3R) [18], which was not used in Hungary at that time.


As long as no organic abnormality was found, part of the sample was offered a small-group consultation. These consultations took place in the presence of the parents (or only the mothers) and the infants on 2 occasions, each lasting 90 min. The consultations were conducted by a pediatric psychotherapist (TN) with the participation of psychologists and psychiatrists from the hospital. During the small-group consultations, the following aspects were spontaneously observed: (a) infant’s developmental level and the quality of his or her playing activity; (b) quality of the parent-infant interactions; (c) emotional reactions between the parents and their moods while together; (d) parent-infant attachment patterns based on the balance between exploration and attachment behaviors; (e) infant’s attitude toward the parents and the professionals in attendance; and (f) ambience of the consultation meeting. At the end of the second meeting, the experiences were discussed with the families in a private meeting, and individual therapy for the parents or parent-infant consultations were offered if necessary. As professionals worked together in a team, they decided by consensus if regulation problems were present and whether additional care was needed due to psychosocial, relationship, or interaction difficulties. In many cases, the 2 small-group consultations were sufficient to resolve mild regulation difficulties.


A questionnaire package was specifically designed for this study. In our edited basic questionnaire, the parents were asked in detail about their family background, housing and job circumstances, their financial status, their health, health-related and psychological characteristics of the pregnancy and the birth of the examined infant, the newborn period, breastfeeding and early care, the infant’s physical and mental condition, and his or her behavioral characteristics. We then focused on the 3 main areas of regulation disorders. Detailed questions were asked about each topic to determine if the infant was affected by intense crying and restlessness, feeding and weight gain difficulties, or sleep disorders. Most of the questions were closed-ended, discrete questions with 2 or more possible answers, or Likert-type scale items, usually with 5 levels. Only the “other” questions were open ended. A pilot study was conducted to ensure that the questions were well understood by the respondents and could be answered easily and reliably. We were not able to measure internal consistency because these questions were single items and did not form scales. In this article, we used only the socio-demographic information and some Likert-type questions on early regulation (crying, sleep, and feeding).


The diagnoses determined in course of medical examinations and during individual and small-group consultations (see the detailed description of the Screening Program above) were included in our database.


Quantitative analyses were performed using IBM SPSS Statistics 20.0 software package (IBM, Armonk, NY, USA).

For the descriptive statistics in this article, we calculated prevalence distributions and for examining associations between regulation problems and other health conditions, we ran crosstabs (χ2-tests) in the cases of diagnoses (yes/no; 1/0 categorical variables) and Mann-Whitney tests in the cases of questionnaire data (Likert-type items, see Table 2).


The Institutional Ethics Committee of Heim Pál Children’s Hospital approved the study (authorization number: 11/04.2010).


Informed consent was obtained from the parents of all individual participants included in the study.


REGULATION DISORDERS IN MEDICAL EXAMINATIONS AND SCREENING PROGRAM: A total of 1133 mothers (Table 1) answered the questionnaires. In a subsample, 619 children had also medical examinations. The sex distribution was almost half and half, male and female, in both groups. The children’s ages and other sociodemographic factors were almost the same or very similar in each subgroup. In the whole sample, the average age of children was 15.3±10.8 months. The average number of children in the families was 1.7±0.9. The average age of the mothers was 32±5.1 years, and more than 90% were married. In addition to medical diagnoses, the main early childhood behavior regulation disorders are also categorized in Table 3. In the subsample in which medical examinations were conducted, excessive crying and/or restlessness was present in 15.0%, sleep disorders in 15.2%, breastfeeding problems in 10.3%, and collective feeding disorders in 14.8%. The prevalence of constipation was 4.0%, while abdominal colic was present in 12.3%. Medical examinations were followed by a deeper screening program for regulation disorders in 183 cases, while in 436 cases this was not necessary. Table 3 presents the prevalence of different disease and disorder categories in each subgroup, showing higher prevalence of regulation disorders in the screening subgroup.

COMORBIDITY BETWEEN DIFFERENT EARLY CHILDHOOD REGULATION DISORDERS: In cases in which excessive crying was present, the comorbidity with sleep disorders was 50% (χ2(1)=106.20; P<0.001); with breastfeeding disorders 22.6% (χ2(1)=17.69; P<0.001); and with loss of appetite 11.8% (χ2(1)=10.70; P<0.001). In those cases in which sleep disorders were present, the comorbidity with breastfeeding disorders was 39.1% (χ2(1)=31.60; P<0.001). Other data are displayed in Table 4.

COMORBIDITY BETWEEN EARLY CHILDHOOD REGULATION DISORDERS AND OTHER HEALTH CONDITIONS: In those cases in which excessive crying was present, the comorbidity with concentration difficulties was 10.8% (χ2(1)=10.71; P<0.001) and with abdominal colic it was 26.9% (χ2(1)=21.67; P=0.001). When sleep disorders or breastfeeding difficulties or organic feeding difficulties were diagnosed, abdominal colic was also present in 21.3% (χ2(1)=8.33; P<0.001), 23.4% (χ2(1)=8.25; P=0.004), and 34.1% (χ2(1)=19.50; P<0.001) of the cases, respectively. Interestingly, pulmonological conditions or recurrent upper airway infections were more frequent in the subgroups in which regulation problems were not a concern. The other relationships are shown in Table 5.

REGULATION DISORDERS IN THE PARENTAL REPORT: According to the questionnaire answers, 14.7% of the mothers’ reported low self-confidence when interpreting their infant’s signs; it was 22.1% in a subgroup that was referred to the screening program. A total of 15.6% of mothers characterized their children as strong criers (24.4% in a subgroup that was referred to the screening program). A total of 16% of the children had some type of feeding or weight gain disorder (32.6% in the screening subgroup), and 10% awoke 4 or more times during the night (21% in the screening subgroup). The frequency of symptoms of crying, feeding, and sleeping per parent reporting are shown in Table 6.


According to the z-statistics in Mann-Whitney tests, mothers of children with a diagnosis of excessive crying reported significantly more problematic crying behavior (long prolonged crying in early infancy: P<0.001, crying and fussiness in the last 2 weeks: P=0.001, soothability: P<0.001, parental distress: P=0.001) compared with those without this diagnosis.

Mothers of children with a diagnosis of loss of appetite or weight loss reported significantly more problematic feeding behavior (feeding as a challenge: P<0.001) compared with mothers of children who did not have this diagnosis.

Children with a diagnosis of sleep disorders had significantly more problematic sleep behavior reported based on the parental questionnaire (nightwakings, sleep onset, parental distress compared with those who did not have this diagnosis; P<0.001 for all differences) using Likert scale in the questionnaire. Detailed results are shown in Table 2.


SLEEPING DISORDERS: In international pediatrician surveys and cross-cultural comparisons, sleeping disorders (night awakenings and sleep-onset difficulties) are one of the most frequent (10–76%) parental concerns [1,2]. In our large sample (N=1133) questionnaire study, 10% of the children had sleeping disorders. In a subsample in which diagnoses were determined based on medical examinations and consultations, we found an incidence of 15.2% for sleep disorders. This rate was similar to reports from other countries [1,2].

EXCESSIVE CRYING: The occurrence of excessive crying was 8–30% in previous large-sample studies [3,24,25]. In our questionnaire study, 15% of mothers reported intensive crying in the infants. In a subsample in which diagnoses were determined based on medical examinations and consultations, we found an incidence of 15.0% of excessive crying and/or restlessness. Prevalence rates for excessive crying were lower in some European countries, with 1.5% in the Netherlands [2] and 9.2% in Denmark [26], but comparable to the 16.3% reported in Germany [27].

EATING DISORDERS: Eating disorders are also common in infancy. Prevalence numbers range from 20% to 25% in the normal population [4,28,29] and from 40% to 80% in infants with disabilities. Mild feeding difficulties occur in approximately 30% of children [4]. The prevalence of clinical feeding disorders is 3–10% [5], and the incidence of more severe failure to thrive is about 3–4% [1].

According to our questionnaire results, 16% of the children had feeding disorders. In a subsample in which diagnoses were determined based on medical examinations and consultations, we found an incidence of 10.3% for breastfeeding disorders and 14.8% for different feeding disorders.

Sleep and feeding disorders are the leading concerns in clinical samples. In a large sample (N=701) in one of the most renowned European clinical programs, the Munich Program [30], occurrence of problems for children were the following: sleep disorders (62.8%), feeding disorders (40.4%), chronic restlessness-motor activity-lack of interest in play (30.1%), excessive crying (29.4%), dysfunctional sleep-wake organization (25.8%), excessive defiance (20.3%), excessive clinging-separation anxiety-social withdrawal (12.3%), and aggression-oppositional behavior (6.8%).

MULTIPLE REGULATORY DISORDERS: Behavioral disorders in infancy can affect an infant’s development [21,22,31,32]. Furthermore, infants with behavioral disorders are more likely to have impaired parent-infant relationships [23,33,34].

Approximately 20% of all infants show symptoms of excessive crying, sleeping, or feeding disorders in the first year of life [31]. The prevalence of colic in infants is about 20%, but it depends on parental perception of crying [35]. In our study, the prevalence was 12.3%. In a systematic review and meta-analysis, colic prevalence at 5–6 weeks of age (25.1%) was significantly higher than colic prevalence at 8–9 weeks of age (10.8%) [36]. Most maternal and child health nurses were unaware of the evidence that crying is not associated with gastro-esophageal reflux, but most of them reported that reflux causes pain [37].

Further, a small minority of children (1–2%) will manifest all 3, leading to multiple regulatory disorders [27,38]. Infants with multiple moderate-to-severe regulatory problems experience >10 times the odds of clinically significant mental health concerns during childhood, and these symptoms appear to worsen over time [39].

COMORBIDITY: Little is known about the association between excessive crying and sleeping or eating disorders in population samples [40]. We found comorbidity among different regulation disorders. Where one type of behavior regulation disorder was present, another type of regulation disorder was more frequently diagnosed (Table 4). Crosstabs (χ2 tests) have proved (P<0.05) that infants who were referred to the screening program because of medical considerations had more frequent behavior regulation disorders than other infants in our study. This, in turn, indicates that the differential diagnostic process was successful in our program.

Wolke et al [41] found that 32.7% of parents reported that their infant had a crying, sleeping, or feeding disorder, and a further 14.6% reported their infant as having more than one of these disorders. Specifically, comorbidity was most likely to occur between crying and sleep disorders. Multiple regulatory problems may identify infants with a high burden of comorbidity that extends into childhood [39,42].

In a retrospective study by von Kries et al [27], a higher prevalence of sleep and eating disorders was found in children up to 4 years of age who were reported to have had excessive crying beyond the sixth month. In our study, the connection between sleep disorders and excessive crying was 50%, but some studies have not found a relationship between excessive crying and sleep disorders and other indicators of multiple regulatory disorders [43], while other studies have found either sleeping or other regulatory disorders [41,44].

The few children with excessive crying and either severe sleeping or eating disorders might constitute a group of infants with multiple regulatory disorders outside the continuous spectrum of normal behavior [40].

Moreover, there is growing evidence of the negative implications for infants whose excessive, persistent crying is present with other regulatory disorders, such as feeding and sleeping disorders [41,45].

A meta-analysis of 22 longitudinal studies showed evidence associating excessive crying and other regulatory disorders (sleeping and eating) in the first months of life with adaptive problems at school age, mainly related to attention deficit-hyperactivity disorder symptoms and associated behaviors [31,32,46,47]. In our study, the comorbidity between excessive crying and concentration difficulties was 10.8%.

There was no connection between regulation and breathing disorders. Breathing stops and sleep disorders were successfully differentiated. Among those diagnosed with sleep disorders, there were fewer infants who had breathing stops than among the others. Also, there was no relationship with symptoms of possible neurological conditions and uncertain sickness or abnormal movements.

Infants who had early activity or concentration disorders were significantly more highly represented among those who had behavior regulation disorders as well. The occurrence of abdominal colic and constipation, symptoms that are often found to have a psychosomatic background, also correlated with the occurrence of other regulation disorders. The occurrence of diagnoses of excessive crying, sleep disorders, and breastfeeding and other feeding disorders was significantly lower in children in whom recurrent upper airway infections, recurrent wheezing, or laryngitis were diagnosed (Table 5).

Questions about both parental observations and subjective feelings were asked in questionnaires. Some important extreme values of questions are presented for the whole sample, for the subsample in which medical examinations were also conducted, and for the subsample that was referred to the screening program. Mothers of infants who were referred to the screening program because of medical considerations reported more problems in the questionnaires than other mothers in our study (Table 6).

The mothers of the infants with diagnoses of excessive crying, sleep, or feeding disorders reported significantly more problematic behavior in questionnaires as well (Table 2).

Our screening program included children who showed signs of regulation disorders and who were referred for a detailed diagnostic evaluation. The incidence of diagnoses in this program was the following: sleep disorders (49.7%), excessive crying (37.2%), and functional feeding disorders (no organic background; 21.3%).

In order to offer appropriate medical support, the differential diagnostic process is important in separating acute secondary symptoms (e.g., crying, mild and transient sleep and feeding disorders because of general discomfort, nonspecific complaints, pain) of frequent child illnesses (eg, respiratory diseases) from comorbid chronic behavior regulation disorders. In our study, we investigated the relationship between regulation disorders and other health conditions from medical records for which a screening model enabled careful and thorough differential diagnostics.

Outpatient treatment is sufficient for crying or sleeping disorders in infancy. However, hospitalization may be required for feeding disorders because not all feeding disorders can be treated on an outpatient basis [48].

In a study conducted by Schmid and Wolke [46], excessive infant crying (10.1%) was specifically associated with maternal anxiety disorders, especially in infants of younger and less educated first-time mothers. Feeding disorders (36.4%) were predicted by maternal anxiety (and comorbid depressive) disorders in primiparous mothers and infants with lower birth weight. Infant sleeping disorders (12.2%) were related to maternal depressive (and comorbid anxiety) disorders irrespective of maternal parity [49–52].

In our experience, designating risk groups in pediatric care is a complex problem. On the one hand, many parents may report regulation disorders, while based on a strict diagnostic system, a clinical disorder cannot be determined. On the other hand, we can assume that there are many hidden cases in which infants could have a clinically relevant regulation disorder but their parents do not interpret these behaviors as being problematic and do not report them to pediatricians or health care nurses. Thus, we can assume that some cases could remain hidden, while in others, study is requested without a clinical basis. In the latter circumstance attention from a therapeutic perspective is still necessary because of the parents’ concern. Questions about the parents’ feelings about the specific problems can contribute to a better understanding of the actual situation.


Most of the data in the current study were collected via maternal reports. These are often limited by social desirability and reporter bias. Another limitation of this study was our lack of access to father-child interactions. Thus, future research should include both mothers and fathers. Another limitation there was no ethnic diversity, with only white participants in the study. It is important to note that our study used only a short period of data collection. Finally, our sample is not representative; the results can be regarded as estimations for recognizing early childhood regulation disorders in pediatric care.


The For Healthy Offspring Project was the first study to examine the prevalence and the complex (medical and psychosocial) background of the classic behavior regulation disorders (excessive crying, feeding, and sleep problems) in infancy and toddlerhood in Hungary. In this article, the relationship between regulation disorders and other health conditions were investigated. Crying and sleep and feeding disorders are challenging for most parents, but only a small fraction of these cases can be categorized as clinical disorders. Although our study is not representative, according to our findings, we can hypothesize that the general incidence of early childhood regulation disorders in international research of 5–15% is likely similar to that found in Hungary as well. This study added more information about the associations between regulation problems and other health conditions. Our model for screening enabled the careful differential diagnostic process of separating acute secondary symptoms from comorbid chronic behavior regulation disorders. We highlighted that no other data are currently available on the frequency and types of early childhood regulation problems in Hungary. In order to effectively recognize early behavior regulation disorders in daily practice, diagnostic instruments widely used in international field should be adapted in general Hungarian pediatric care.


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13 October 2021 : Editorial

Editorial: Global Initiatives Support the Use and Regulation of Digital Health Technology During the COVID-...

Med Sci Monit In Press; DOI: 10.12659/MSM.935123  

11 October 2021 : Clinical Research

Clinical Features and Temporal Lung Radiographic Changes in 25 Patients Recovering from COVID-19 Pneumonia:...

Med Sci Monit In Press; DOI: 10.12659/MSM.933381  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

12 October 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit 2021; 27:e930776

In Press

13 Oct 2021 : Editorial

Editorial: Global Initiatives Support the Use and Regulation of Digital Health Technology During the COVID-...

Med Sci Monit In Press; DOI: 10.12659/MSM.935123  

13 Oct 2021 : Clinical Research

Endovascular Repair of Thoracic Aorta Injury: 17 Years of Single-Center Experience

Med Sci Monit In Press; DOI: 10.12659/MSM.934479  

11 Oct 2021 : Clinical Research

Challenges for Polish Community Pharmacists in Provision of Services to Immigrants and Non-Polish-Speakers ...

Med Sci Monit In Press; DOI: 10.12659/MSM.933678  

11 Oct 2021 : Clinical Research

Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors

Med Sci Monit In Press; DOI: 10.12659/MSM.933782  

Most Viewed Current Articles

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750