04 January 2022>: Animal Study
Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 PathwayKun Cao 12BCEF , Jie Xiang 13CF , Yang-Ting Dong 34BCD , Yi Xu 13CD , Zhi-Zhong Guan 134ADG*
Med Sci Monit 2022; 28:e933978
Figure 4 Immunohistochemical staining for senile plaques in the hippocampus of APP/PS1 mice at 10 months of age. (A–I) Staining senile plaques in the hippocampus. (J) The numbers of senile plaques detected. Magnification: A, D and G, 40×, scale bar=250 μm; B, E and H, 100×, scale bar=500 μm; C, F and I, 200×, scale bar=50 μm. The solid arrows indicate senile plaques. The values presented are means±SD of n=10 mice. * P<0.05 compared to the wild-type (WT) group, as determined by analysis of variance (ANOVA), followed by the Tukey HSD test.