04 January 2022>: Animal Study
Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 PathwayKun Cao 12BCEF , Jie Xiang 13CF , Yang-Ting Dong 34BCD , Yi Xu 13CD , Zhi-Zhong Guan 134ADG*
Med Sci Monit 2022; 28:e933978
Figure 1 Effects of an activator of α7 nAChR on learning and memory in APP/PS1 mice at 6 or 10 months of age. The PNU was dissolved in sterile 0.9% saline and the pH adjusted to 7.0. The APP/PS1 mice at the ages of 6 and 10 months, respectively, were intraperitoneally received PNU (1 mg/kg) for APP/PS1 mice or physiological saline for wild-type (WT) animals for 2 days before and during the 5 acquisition days of the Morris water maze test. (A) Escape latency. (B) The number of platform crossings. (C) Time spent at the original position of platform. The values presented are means±SD of n=10 mice. * P<0.05 compared with the WT group; # P<0.05 compared with the APP/PS1 group, as determined by analysis of variance (ANOVA), followed by the Tukey HSD test.