10 October 2021: Animal Study
Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model
Yong-feng Wang 1E* , Yan Luo 2C* , Gao-lei Hou 1B , Rui-jing He 3C , Hao-yun Zhang 3F , Yan-Li Yi 3D , Ying Zhang 3B , Zhi-qiang Cui 3AG*DOI: 10.12659/MSM.933469
Med Sci Monit 2021; 27:e933469
Figure 4 Effect of methylene blue (MB) on kainic acid (KA)-induced epileptiform activity in vivo. (A) Representative tracings showing KA-induced epileptiform activity for the full recording period in vivo in mice pretreated with vehicle, 0.5 mg/kg of MB, and 1 mg/kg of MB, respectively. Electroencephalogram tracings are labeled to indicate drug administration times (vehicle, MB, and KA) accordingly. Histograms showing the latency (minutes) (B), average epileptiform duration (minutes) (C), and epileptiform activity (percentage) (D) of epileptiform activity in KA-treated mice in different group. Values are expressed as means±standard error of the mean. (n=11 vehicle+KA group, n=12 MB 0.5 mg/kg or 1 mg/kg+KA group). # P<0.05 vs vehicle+KA group; & P<0.05 vs MB 0.5 mg/kg+KA group. (Prism 8, version 8.3.0).