10 October 2021>: Animal Study
Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model
Yong-feng Wang 1E* , Yan Luo 2C* , Gao-lei Hou 1B , Rui-jing He 3C , Hao-yun Zhang 3F , Yan-Li Yi 3D , Ying Zhang 3B , Zhi-qiang Cui 3AG*DOI: 10.12659/MSM.933469
Med Sci Monit 2021; 27:e933469
Figure 1 Chemical structure and redox balance of methylene blue (MB). MB has powerful autoxidizable properties. It can accept electrons from an electron donor in its oxidized form and acts as an electron donor in its reduced form. At low concentrations in vivo, the 2 forms of MB are at equilibrium, forming a reversible reduction-oxidation system.