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18 October 2021: Lab/In Vitro Research

Salicylate Induced GABAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons

Jiangyuan Qin ABCDEF , Tingjia Wei BCD , Huiying Chen BCD , Xiaoyu Lin BC , Danxue Qin BC , Fangyu Wei BC , Peiqiang Liu BC , Wenhua Ye BC , Jiping Su ADG*

DOI: 10.12659/MSM.933278

Med Sci Monit 2021; 27:e933278

Figure 5 GABA-activated currents recorded in SGNs. (A, B) The suppression of 5 mM SS on GABA-activated currents was reduced by inhibiting D1Rs, then further reduced following co-inhibiting D1Rs and PKC. Data are presented as mean±SD. n=7. * P<0.05 vs GABA group, # P<0.05, vs the SKF group, & P<0.05 vs the SS group, Δ P<0.05, SS+SKF+SCH group vs SS+SKF+SCH+Bis I group, by one-way ANOVA and Tukey test. Pulsefit 8.61 (HEKA, USA) and SPSS 25.0 (USA) were used for the creation of the figures.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750