18 October 2021: Lab/In Vitro Research
Salicylate Induced GABAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons
Jiangyuan Qin ABCDEF , Tingjia Wei BCD , Huiying Chen BCD , Xiaoyu Lin BC , Danxue Qin BC , Fangyu Wei BC , Peiqiang Liu BC , Wenhua Ye BC , Jiping Su ADG*DOI: 10.12659/MSM.933278
Med Sci Monit 2021; 27:e933278
Figure 4 Phosphorylation of S327 of GABAAR γ2 subunit in SGNs. (A) SKF markedly enhanced the phosphorylation levels of S327 (expression of the p-327 protein was normalized to βIII-tubulin) as compared to the control group, which was partially reversed by inhibiting PKC. (B) SS, SS+SKF markedly enhanced the phosphorylation levels of S327 as compared to the control group, which was partially reversed by inhibiting D1Rs or PKC. Data are presented as mean±SD. All experiments n=4, * P<0.05, vs the control group, # P<0.05, vs the SKF group, & P<0.05 vs the SS group, by one-way ANOVA and Tukey test. Odyssey 3.0.23 (LI-COR, USA) and SPSS 25.0 (USA) were used for the creation of the figures.