17 August 2021: Animal Study
Microarray Analysis of Differential Gene Expression Between Traumatic Temporomandibular Joint Fibrous and Bony Ankylosis in a Sheep Model
Tong-Mei Zhang 1BCDEF* , Kun Yang 2BCD* , Su-Xia Liang 3AB , Pei-Pei Zhang 4AB , Hua-Lun Wang 1BD , Yuan-Yuan Tian 1CD , Zhao-Yuan Xu 1BC , Hao Liu 1ABCDG* , Ying-Bin Yan 1ABCDEFG*DOI: 10.12659/MSM.932545
Med Sci Monit 2021; 27:e932545
Figure 6 PPI network construction and Module analysis of the DEGs at day 28. (A) The PPI network of the DEGs consisted of 222 nodes and 511 edges. (B) The top 10 highly connected genes with 28 edges of PPI network. (C) The most significant module consisting of 10 nodes and 40 edges extracted from PPI network (MCODE score=8.889). The nodes represent proteins, and the edges between nodes represent interactions. The greater the degree of correlation, the larger the diameter of nodes. The nodes are red for upregulation in TMJ bony ankylosis, and blue for upregulation in fibrous ankylosis. PPI – protein–protein interaction; DEGs – differentially expressed genes.