Figure 7 (A, B) Expression of SIK3, PSD-95 and proteins associated with tau modification after administration of tau agonist in ratsIntravenous anesthesia with propofol reversed cognitive impairment caused by acute sleep deprivation. In the Control group, the expression level of tau protein in the hippocampus of the SD group was upregulated (P<0.05), the expression level of tau protein phosphorylation (Ser404) was significantly upregulated (P<0.05), and the acetylation level was decreased (P<0.05), together with the decrease in postsynaptic PSD95. There was no significant difference in each protein’s levels between the Prop group and the Control group (P>0.05). The SD+Prop group outperformed the SD group in cognition, and the results were statistically significant (* P<0.05 Con vs SD, Control vs Prop, and SD vs SD+Prop).