26 September 2021>: Animal Study
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different FactorsMengxi Shen 12ABCDEF* , Naqi Lian 12BCE* , Chengcheng Song 12DE , Chao Qin 12BD , Yang Yu 12AE* , Yonghao Yu 12ABE*
Med Sci Monit 2021; 27:e932422
Figure 7 (A, B) Expression of SIK3, PSD-95 and proteins associated with tau modification after administration of tau agonist in ratsIntravenous anesthesia with propofol reversed cognitive impairment caused by acute sleep deprivation. In the Control group, the expression level of tau protein in the hippocampus of the SD group was upregulated (P<0.05), the expression level of tau protein phosphorylation (Ser404) was significantly upregulated (P<0.05), and the acetylation level was decreased (P<0.05), together with the decrease in postsynaptic PSD95. There was no significant difference in each protein’s levels between the Prop group and the Control group (P>0.05). The SD+Prop group outperformed the SD group in cognition, and the results were statistically significant (* P<0.05 Con vs SD, Control vs Prop, and SD vs SD+Prop).