26 September 2021>: Animal Study
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different FactorsMengxi Shen 12ABCDEF* , Naqi Lian 12BCE* , Chengcheng Song 12DE , Chao Qin 12BD , Yang Yu 12AE* , Yonghao Yu 12ABE*
Med Sci Monit 2021; 27:e932422
Figure 4 (A, B) Behavioral changes of MWM test in ratsMorris water maze test. Compared with the Control group, the change of propofol group was small but statistically significant. The acute sleep group and inhalation of sevoflurane group had significantly increased escape latency, and the alternation rate was decreased. Compared with the SD group, sleep deprivation combined with sevoflurane inhalation induced more apparent cognitive impairment, and the difference was statistically significant. However, the cognitive function of the SD combined with propofol group was not significantly different from that of the Control group. (* p<0.05, Control vs SD, Control vs Sevo, SD vs SD+Sevo).