26 September 2021>: Animal Study
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors
Mengxi Shen 12ABCDEF* , Naqi Lian 12BCE* , Chengcheng Song 12DE , Chao Qin 12BD , Yang Yu 12AE* , Yonghao Yu 12ABE*DOI: 10.12659/MSM.932422
Med Sci Monit 2021; 27:e932422
Figure 10 Change in hippocampal dendritic spines after administration of Tau modification agonistIn the DG region, dendritic spines’ density was decreased in the SD and Prop groups compared with before. The dendritic spines in DG and CA 1 regions in the SD+Prop group were denser than those in the Control group, suggesting that the effects of sleep deprivation and intravenous anesthesia on cognitive function can eventually change synaptic plasticity, thus affecting long-term cognitive function. Propofol infusion had a definite reversal effect on cognitive dysfunction caused by sleep deprivation.