04 June 2021>: Animal Study
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent MechanismHuiying Pan 1BC , Yi Xu 2D , Qian Cai 1E , Meiling Wu 1ABD , Mingxing Ding 1AG*
Med Sci Monit 2021; 27:e931884
Figure 1 β-asarone ameliorates ischemic brain injury in MCAO rat models. (A) Contextual fear conditioning test for rats 24 h before modeling and 24 h after modeling. (B, C) TTC staining for assessment of the infarct volumes in brain tissues for control, model, and model rats treated with β-asarone and/or Nrf2 inhibitor for consecutive 20 days. Ns – not significant; * p<0.05, ** p<0.01, **** p<0.0001.