02 October 2021: Clinical Research
Preoperative Alkaline Phosphatase-to-Cholesterol Ratio as a Predictor of Overall Survival in Pancreatic Ductal Adenocarcinoma Patients Undergoing Radical Pancreaticoduodenectomy
Guotong Qiu ABCDEF , Lipeng Zhang BD , Zongting Gu CD , Hu Ren BC , Yongxing Du DF , Zongze Li B , Chengfeng Wang DFG*DOI: 10.12659/MSM.931868
Med Sci Monit 2021; 27:e931868
Figure 1 Receiver-operating characteristic (ROC) curve analysis based on preoperative alkaline phosphatase (ALP) concentration, cholesterol (CHO) level, and ALP/CHO ratio (ACR) for overall survival. The area under the ROC curve (AUC) indicates the diagnostic power of ALP, CHO, and ACR. The optimum cutoff point for ALP concentration was 108.5 U/L, and AUC was 0.719 (95% confidence interval [CI], 0.578–0.859), with a sensitivity of 78.6% and a specificity of 33.3% by the Youden index. The optimum cutoff point for CHO level was 3.49 mmol/L, and AUC was 0.521 (95% CI, 0.365–0.678), with a sensitivity of 81.0% and a specificity of 66.7% by the Youden index. The optimum cutoff point for ACR was 32.988, and AUC was 0.737 (95% CI, 0.615–0.859), with a sensitivity of 75.0% and a specificity of 27.8% by the Youden index.