20 August 2021: Animal Study
Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis
Cuizhen Long 123ABCDEF* , Na Xie 12ABCDEF* , Yuanhui Shu 12ABCF , Yafeng Wu 14ABCF , Ping He 12BC , Yan Zhou 12BC , Yining Xiang 5CD , Junying Gu 12CD , Lei Yang 12DF , Yuping Wang 12ABCDEFG*DOI: 10.12659/MSM.931236
Med Sci Monit 2021; 27:e931236
Figure 5 (A, B) Expression of A20 and p-NF-κB p65 in liver tissue of 4 groups. Deletion of cannabinoid receptor 2 promoted the expression of A20 and p-NF-κB p65 in liver tissue. A20, tumor necrosis factor alpha-induced protein 3; p-NF-κB p65, phosphorylated nuclear factor-κB p65. # P<0.05 compared with the WT control group, * P<0.05 compared with the CB2−/− control group, and & P<0.05 compared with the WT model group.