RNA N6-Methyladenosine Patterns in Hepatocellular Carcinoma Reveal a Distinct Immune Infiltration Landscape and Clinical Significance

Hua Zhao; Qiujun Zhou; Chengwei Shi; Yaojian Shao; Junjie Ni; Jianying Lou; Shenyu Wei

doi:10.12659/MSM.930994

25 October 2021: Database Analysis

RNA N6-Methyladenosine Patterns in Hepatocellular Carcinoma Reveal a Distinct Immune Infiltration Landscape and Clinical Significance

Hua Zhao ^1CEFG , Qiujun Zhou ^2BDEF , Chengwei Shi ^2CD , Yaojian Shao ^2CD , Junjie Ni ^2CD , Jianying Lou ^3ACE* , Shenyu Wei ^2ACEF*

DOI: 10.12659/MSM.930994

Med Sci Monit 2021; 27:e930994

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Figure 7 The correlation between clinical characteristic and N6-methyladenosine (m6A) risk score. (A) The m6A risk score was significantly negatively correlated with infiltration of protective immune cell types in hepatocellular carcinoma. (B) The correlation between m6A risk score and pathologic stage. (C) The correlation between m6A risk score and pathologic grade. (D) Sankey diagram of m6A risk score in classification with different methylation modification patterns, immune infiltration status, and survival outcomes. R (version 3.6.1) software was used to create the pictures.

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RNA N6-Methyladenosine Patterns in Hepatocellular Carcinoma Reveal a Distinct Immune Infiltration Landscape and Clinical Significance

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