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25 October 2021: Database Analysis

RNA N6-Methyladenosine Patterns in Hepatocellular Carcinoma Reveal a Distinct Immune Infiltration Landscape and Clinical Significance

Hua Zhao 1CEFG , Qiujun Zhou 2BDEF , Chengwei Shi 2CD , Yaojian Shao 2CD , Junjie Ni 2CD , Jianying Lou 3ACE* , Shenyu Wei 2ACEF*

DOI: 10.12659/MSM.930994

Med Sci Monit 2021; 27:e930994

Figure 4 Potential roles of the LRPPRC N6-methyladenosine (m6A) modulator in immune microenvironment formation and hepatocarcinogenesis. (A) Differences in human leukocyte antigen molecule expression between LRPPRC high-expression and low-expression groups. (B) Differences in immune components between LRPPRC high-expression and low-expression groups. (C) Gene set enrichment analysis reveals the significant Kyoto Encyclopedia of Genes and Genomes pathways enriched in patients with high LRPPRC expression. (D) Representative LRPPRC immunohistochemical staining in normal liver tissues and those from patients with hepatocellular carcinoma in the Human Protein Atlas database. (E) Kaplan-Meier curve survival analyses for The Cancer Genome Atlas cohort patients with high and low LRPPRC expression. R (version 3.6.1) software was used to create the pictures.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750