Figure 1 The landscape of N6-methyladenosine (m6A) methylation modulator-related genetic aberration in hepatocellular carcinoma (HCC). (A) The frequency of copy number variation (CNV) for 21 m6A modulators in The Cancer Genome Atlas (TCGA) cohort. The red point represents amplification frequency and the blue point represents deletion frequency. (B) Circle plot of the specific location of the CNV of 21 m6A modulators in the human chromosomes. (C) The somatic mutation profile of m6A modulators in 364 patients with HCC from the TCGA cohort. (D) Principal component analysis for samples from International Cancer Genome Consortium and TCGA cohorts. Tumor samples could be well distinguished from normal samples based on the expression profile of the 21 m6A modulators. Normal samples are labeled with yellow and tumor samples are labeled with blue. (E) Expression variation of m6A modulators: comparison between normal tissues and tumor tissues from the TCGA cohort. The black lines in boxes represent the median value and black points represent the outliers. Statistical significance is represented by asterisks (*** P<0.001; ** P<0.01; * P<0.05). R (version 3.6.1) software was used to create the pictures.