19 August 2021: Lab/In Vitro Research
Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer via Upregulation of Integrin αvβ6
Ben Wang 1ABEG , Shanjie Wang 2B , Wenke Wang 3BC , Enyu Liu 1BD , Sen Guo 1EF , Chuanzong Zhao 1CF , Jun Niu 1AD* , Zongli Zhang 1A*DOI: 10.12659/MSM.930921
Med Sci Monit 2021; 27:e930921
Figure 3 High glucose induced upregulation of integrin β6. HT-29 and WiDr cells were incubated with medium containing various concentrations of glucose for 24 h, and expression of integrin β6 and αv was measured by real-time PCR (A, B) and western blot (C, D). (E) Expression of integrin β1, β3, and β5 was detected by real-time PCR in HT-29 cells. Mean±SD of 3 independent experiments. * P<0.05 vs control. OC – osmotic control; NG – normal glucose; HG – high glucose.