08 May 2021>: Review ArticlesLongfei Yang 1ABCDE , Xiaofeng Zou 2G , Junrong Zou 3D , Guoxi Zhang 2FG*
Med Sci Monit 2021; 27:e930639
Figure 1 Representative diagram of miRNAs acting as tumor suppressors, and their associated signaling pathways in renal cancer. The drawing mainly illustrates that miR-125a-3p/363 and miR-205-5p/148b-3p/299-3p/765 inhibit the VEGF and VEGFA signaling pathways through decreasing the expression of VEGF and VEGFA, respectively. miR-199a, miR-106a-5p, miR-384, and miR-532-5p/622/363/200b/10a-5p restrain RAS/MAPK signaling pathways by decreasing the levels of Rock1, PAK5, AEG-1, and p-ERK, respectively. Furthermore, miR-338-3p/488/15a, miR-218/766-3p/148a/218, miR-375/409-3p, miR-126, miR-100, and miR-320a/149 influence the PI3k/AKT/mTOR signaling pathways by decreasing the levels of PI3k, p-AKT, PDK1, p-mTOR, mTOR, and FOXM1, respectively. In contrast, miR-520/372/373/203 increases the expression of PTEN and exerts the same effect. miR-328 and miR-486-5p inhibit the TGF-β signaling pathways through decreasing the expression of TGF-β1 and TAK1, respectively. miR-186 and miR-216a influence NF-κB signaling pathways by decreasing the levels of p-p65 and TLR4, respectively. In addition, miR-497-5p targets PD-L1, thus influencing immunity-related mechanisms. VEGF – vascular endothelial growth factor; Rock1 – Rho-associated coiled-coil-forming protein kinase; PAK5 – p21-activated kinase 5; AEG-1 – AEG-1-astrocyte-elevated gene-1; p-ERK – phosphorylate extracellular signal regulated kinase; PI3k – phosphatidylinositol 3-kinase; p-AKT – p-protein kinase B; PDK1 – phosphoinositide-dependent kinase 1; mTOR – mammalian target of rapamycin; FOXM1 – forkhead box M1; PTEN – phosphatase and tensin homolog deleted on chromosome 10; TGF-β1 – transforming growth factor-β 1; TAK1 – TGF-beta-activated kinase 1; PLP2 – proteolipid protein 2; INF; TLR4 – toll-like receptor 4; PD-L1 – programmed death ligand 1.