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19 May 2021: Animal Study

Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway

Wen-yu Bian 1BC* , Ya-ping Chen 2DF* , Bo Xu 3AE* , Jun Tang 4AE*

DOI: 10.12659/MSM.930478

Med Sci Monit 2021; 27:e930478

Figure 2 (A, B) Pulmonary static compliance and airway resistance at T0 (15 min after intubation), T1 (2 h after ischemia), T2 (2 h after reperfusion), and T3 (4 h after reperfusion) in the sham, IIR+NS, and IIR+P groups. Data are expressed as the mean±SD (n=8). * P<0.05, ** P<0.01 compared with the sham group, # P<0.05 compared with the IIR+NS group. IIR – intestinal ischemia-reperfusion; NS – normal saline; P – propofol.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750