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03 April 2021: Animal Study

Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway

Zhao Hui 1BF , Huang Jie 2CD , Guo-Hua Fan 2ABCDEFG*

DOI: 10.12659/MSM.930429

Med Sci Monit 2021; 27:e930429

Figure 8 JNK inhibition blocked the DUSP12 knockdown-mediated worsening of ALI in mice. (A) H&E staining (n=5, magnification: 200). (B) Lung wet weight/dry weight ratio (D/W ratio) (n=10). (C) Lung injury score (n=6). (D) Proinflammatory factor levels in alveolar lavage fluid as measured by ELISA (n=6) (* P<0.05 vs Ad-shDUSP12-LPS, NS – not significant).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750