20 August 2021: Clinical Research
Association of Plasma Pro-Brain-Derived Neurotrophic Factor (proBDNF)/Mature Brain-Derived Neurotrophic Factor (mBDNF) Levels with Gene Val66Met Polymorphism in Alcohol Dependence
Min Mo 1BCDEG* , Xi-yue Fu 2BCDF* , Xu-lan Zhang 1BD , Shao-chuan Zhang 1BD , Hai-qing Zhang 1CD , Li Wu 1AF , Jia-lei Li 1AF , Li Zhou 1ACEFG*DOI: 10.12659/MSM.930421
Med Sci Monit 2021; 27:e930421
Figure 1 The plasma level of proBDNF was increased and mBDNF was decreased in the patients with alcohol dependence compared with controls. (A) The plasma level of proBDNF in the patients was significantly higher than in the controls (Z=−2.228, P=0.026, Mann-Whitney U test). (B) The plasma level of mBDNF in the patients was significantly reduced compared with the controls (Z=−2.014, P=0.044, Mann-Whitney U test). mBDNF – mature brain-derived neurotrophic factor; proBDNF – pro-brain-derived neurotrophic factor.