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11 June 2021: Animal Study

Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

Dong Sun 1BCDEF* , Liu Yang 1BCEF* , Weiping Zheng 23CE , Huan Cao 14BD , Longlong Wu 5DF , Hongli Song 26AG*

DOI: 10.12659/MSM.930258

Med Sci Monit 2021; 27:e930258

Figure 2 Evaluation of the NMP system and BMMSCs. (A) Morphology characteristics of third-generation BMMSCs; (B) Adipogenic induction; (C) Osteogenic induction; (D) Bright-field image of GFP-BMMSCs; (E) Fluorescent image of GFP-BMMSCs showing that >85% of the cells are transduced with GFP; (F) Fluorescent image of DCD donor liver perfused by BMMSCs combined with NMP at 6 h, the arrow indicates GFP-BMMSCs colonized in hepatic sinusoids. BMMSCs – bone marrow mesenchymal stem cells; GFP – green fluorescent protein; NMP – normothermic machine perfusion.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750