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01 June 2021: Animal Study

Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)

HuaiMing Wang 1A , YiQuan Xu 1B , Shuying Zhu 1E , XueMing Li 2F , HongWei Zhang 1G*

DOI: 10.12659/MSM.930042

Med Sci Monit 2021; 27:e930042

Figure 1 Sevoflurane post-treatment attenuates cognitive impairment in HIBI neonatal rats. (A) Escape latency of rats in each group assessed by Morris water maze test, N=18, # P<0.001, Sham group vs HI group; * P<0.001, HI group vs HI+S group. (B) The platform crossing times of rats in each group measured by spatial probe test, N=18. (C) The cerebral infarct size in rats of each group measured by TTC staining, N=6. The data are expressed as the mean±standard deviation. The data between groups were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. * P<0.05.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750