Figure 3 TCONS_00068220 promotes breast cancer cell growth in vivo. (A) Effects of TCONS_00068220 knockdown on tumor growth in vivo. Left: Representative images of tumors formed in nude mice injected subcutaneously with the TCONS_00068220-depleted MDA-MB-231 cells. Middle: tumor weights. Right: tumor volumes. Tumors derived from cells with TCONS_00068220 overexpression were substantially smaller than the control group. (B) Effects of TCONS_00068220 overexpression on tumor growth in vivo. Left: Representative images of tumors formed in nude mice injected subcutaneously with MCF-7 cells overexpressing TCONS_00068220. The tumor weight (middle) and tumor volume (right) were markedly increased in the pLVX-TCONS_00068220 group compared with the control group. * P<0.05; ** P<0.01.