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21 June 2021: Lab/In Vitro Research

Salvianolic Acid A Protects H9C2 Cardiomyocytes from Doxorubicin-Induced Damage by Inhibiting NFKB1 Expression Thereby Downregulating Long-Noncoding RNA (lncRNA) Plasmacytoma Variant Translocation 1 (PVT1)

Yumeng Wu 1ABF , Wei Xiu 2CD , Yubo Wu 1AEF*

DOI: 10.12659/MSM.929824

Med Sci Monit 2021; 27:e929824

Figure 4 The interaction between nuclear factor kappa B subunit 1 (NFKB1) and plasmacytoma variant translocation 1 (PVT1) in H9C2 cells. (A) The binding sequences between NFKB1 and lncRNA PVT1 promoter. (B, C) The mRNA and protein expression of NFKB1 in H9C2 cells overexpressed with NFKB1 or not. (D) PVT1 expression in H9C2 cells overexpressed with NFKB1 or not. (E, F) The interaction between NFKB1 and PVT1 was confirmed by luciferase report (E) and chromatin immunoprecipitation (F) assays. *** P<0.001.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750