05 June 2021: Animal Study
Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model
Yiming Zhang 1A* , Miaomiao Ma 2A* , Jun Li 3D , Yingye Wu 2C , Lu Xue 2C , Rongrong Zhao 2B , Lu Wang 2E , Shuping Hou 2G* , Huiping Wang 2G*DOI: 10.12659/MSM.929781
Med Sci Monit 2021; 27:e929781
Figure 1 The phenotype of dorsal skin in different treatment groups observed on days 2, 4, 6, and 8. (A) Normal, (B) imiquimod (IMQ), (C) phosphate-buffered saline intramuscular injection (IM-PBS), (D) pGP3 intramuscular injection (IM-pGP3), and (E) pGP3M intramuscular injection (IM-pGP3M) groups. The IMQ, IM-PBS, IM-pGP3, and IM-pGP3M groups exhibited psoriasis-like dermatitis signs including erythema, skin scaling, and thickening after IMQ application. The typical signs of psoriasis-like dermatitis decreased after the sixth day in the IM-pGP3, and IM-pGP3M groups. Compared with the IMQ and IM-PBS groups, the IM-pGP3 and IM-pGP3M groups exhibited milder skin lesions and shorter healing time.