21 April 2021>: Animal Study
Short-Term High-Intensity Treadmill Exercise Promotes Ceramide-Dependent Extracellular Vesicle Secretion in the Central Nervous System of MiceRui Zhang 12ABCEF* , Xiaoyan Liang 1BC* , Shi Tang 1BC , Lin Song 1CD , Jing Zhang 1CF , Yifeng Du 1AG*
Med Sci Monit 2021; 27:e929609
Figure 2 Short-term high-intensity exercise increased the levels of EV biomarkers in the mouse serum. (A) Western blot shows the indicated biomarkers in serum from mice sacrificed before exercise (control), immediately after exercise (0 min) and 90 min after exercise (90 min). (B) The serum level of TSG101 showed no significant increase (P>0.05). (C) The serum level of CD63 showed no apparent changes (P>0.05). (D) The HSC70 level was markedly higher after exercise than before exercise (p<0.01); n=8/group. Data are expressed as the mean±SD; * P<0.05, ** P<0.01 using one-way ANOVA with the Bonferroni post-test.