21 April 2021>: Animal Study
Short-Term High-Intensity Treadmill Exercise Promotes Ceramide-Dependent Extracellular Vesicle Secretion in the Central Nervous System of MiceRui Zhang 12ABCEF* , Xiaoyan Liang 1BC* , Shi Tang 1BC , Lin Song 1CD , Jing Zhang 1CF , Yifeng Du 1AG*
Med Sci Monit 2021; 27:e929609
Figure 1 Short-term high-intensity exercise increased the levels of EV markers in the mouse hippocampus. (A) A paraffin section of mouse hippocampus obtained immediately after exercise is co-stained with anti-TSG101 and anti-Tuj1; Scale bar: 50 μm. (B) Mice in the exercise group show higher hippocampal neuron levels of TSG101 compared with the non-exercise group; n=8/group. Data are expressed as the mean±SD; ** p<0.01 using the t test. (C) A paraffin section of the hippocampus from mice after exercise was co-stained using anti-HSC70 and anti-Tuj1; Scale bar: 50 μm. (D) Mice in the exercise group showed higher hippocampal neuron levels of HSC70 compared with the non-exercise group; n=8/group. Data are the mean±SD; * p<0.05 using the t test.