14 April 2021>: Animal Study
Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling PathwaysJingwen Zhou 1ABCE* , Xiaolong Zhang 1A* , Lingfeng Wan 1AD , Jun Yu 2BCD , Tianci Li 2BCD , Ziyu Lu 3BCD , Nanyuan Fang 1E , Lixia Sun 1AG* , Fang Ye 2AG*
Med Sci Monit 2021; 27:e929438
Figure 5 Toll-like receptor 4 (TLR4)-related nuclear factor kappa b (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways were inhibited by Zi Qi decoction in vivo. (A) Messenger RNA expression of TLR4, MyD88, and TRAF6 in liver tissue in each group. (B) Protein expression of TLR4, MyD88, TRAF6, and phospho-NF-κB p65 in liver tissue in each group. (C) Expression of MAPK pathway-related proteins and their relative phosphorylation levels in liver tissue in each group. # P<0.05, compared with the control group. * P<0.05, *** P<0.001, compared with the vehicle group. Data were presented as means±standard deviations.